Haematologica. 1991 Sep-Oct;76(5):424-5.

Severe neutropenia in a patient with large granular lymphocytosis: prolonged successful control with cyclosporin A.

Source

B' Propedeutic clinic of Internal Medicine, Aristotelion University of Thessaloniki, Ippokration General Hospital, Greece.

Abstract

A case of severe neutropenia associated with large granular lymphocytosis in a 40-year-old female is described. The patient, with no findings of an underlying systemic disorder, had suffered from recurrent life threatening, mainly pseudomonal, infections for about two years, despite the various regimes tried. During the last twelve months cyclosporin A treatment resulted in a significant increase in absolute neutrophil counts, concomitant with a remarkable decrease in bone marrow infiltration by GLs and almost normal counts of GLs in the peripheral blood. During this time she has remained completely free from infectious episodes. The mechanisms involved remain to be determined.

PMID:: 1806448; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

Cyclosporine

LinkOut - more resources

Molecular Biology Databases

CYCLOSPORIN A - HSDB

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Treatment of chronic neutropenia associated with large granular lymphocytosis with cyclosporine A and filgrastim. [Am J Hematol. 1995]
Treatment of chronic neutropenia associated with large granular lymphocytosis with cyclosporine A and filgrastim.
Jakubowski A, Winton EF, Gencarelli A, Gabrilove J. Am J Hematol. 1995 Dec; 50(4):288-91.
Severe neutropenia associated with large granular lymphocyte lymphocytosis: successful control with cyclosporin A. [Blut. 1989]
Severe neutropenia associated with large granular lymphocyte lymphocytosis: successful control with cyclosporin A.
Pastor E, Sayas MJ. Blut. 1989 Dec; 59(6):501-2.
Neutropenia associated with T-cell large granular lymphocyte leukemia: long-term response to cyclosporine therapy despite persistence of abnormal cells. [Blood. 1998]
Neutropenia associated with T-cell large granular lymphocyte leukemia: long-term response to cyclosporine therapy despite persistence of abnormal cells.
Sood R, Stewart CC, Aplan PD, Murai H, Ward P, Barcos M, Baer MR. Blood. 1998 May 1; 91(9):3372-8.
Review Response of T-beta CD8+ lymphocytosis-associated neutropenia to G-CSF. [Br J Haematol. 1994]
Review Response of T-beta CD8+ lymphocytosis-associated neutropenia to G-CSF.
Vickers M, Stross P, Millard P, Barton C. Br J Haematol. 1994 Jun; 87(2):431-3.
Review [Chronic granular T lymphocytosis of undetermined significance]. [Recenti Prog Med. 1989]
Review [Chronic granular T lymphocytosis of undetermined significance].
Paladini G, Mazzanti G, Parma A, Zacchi T. Recenti Prog Med. 1989 May; 80(5):252-60.

See reviews... See all...

Cited by 1 PubMed Central article

Review Primary and secondary autoimmune neutropenia. [Arthritis Res Ther. 2005]
Review Primary and secondary autoimmune neutropenia.
Capsoni F, Sarzi-Puttini P, Zanella A. Arthritis Res Ther. 2005; 7(5):208-14. Epub 2005 Aug 31.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Severe neutropenia in a patient with large granular lymphocytosis: prolonged suc...
Severe neutropenia in a patient with large granular lymphocytosis: prolonged successful control with cyclosporin A.
Haematologica. 1991 Sep-Oct ;76(5):424-5.

PubMed
Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attri...
Small intestinal CD8+TCRgammadelta+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease.
J Clin Invest. 2008 Jan ;118(1):281-93.

PubMed
Collagen-induced arthritis--characteristics of the animal model and implications...
Collagen-induced arthritis--characteristics of the animal model and implications for the treatment of autoimmune disease.
Chin Med Sci J. 1991 Jun ;6(2):78-83.

PubMed
Emerging viral infections and arthritis: the role of the rheumatologist.
Emerging viral infections and arthritis: the role of the rheumatologist.
Nat Clin Pract Rheumatol. 2008 Jan ;4(1):2-3. Epub 2007 Nov 27 .

PubMed
Interleukin-8 as a mediator of sympathetic pain.
Interleukin-8 as a mediator of sympathetic pain.
Br J Pharmacol. 1991 Nov ;104(3):765-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: