Nat Genet. 2008 Jan;40(1):23-5. Epub 2007 Dec 2.

Psoriasis is associated with increased beta-defensin genomic copy number.

Hollox EJ, Huffmeier U, Zeeuwen PL, Palla R, Lascorz J, Rodijk-Olthuis D, van de Kerkhof PC, Traupe H, de Jongh G, den Heijer M, Reis A, Armour JA, Schalkwijk J.

Source

Department of Genetics, University of Leicester, Leicester LE1 7RH, UK.

Abstract

Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.

Comment in

Nat Genet. 2008 Jan;40(1):5-6.

PMID:: 18059266; [PubMed - indexed for MEDLINE]
PMCID: PMC2447885

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Research Support, Non-U.S. Gov't

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071024/Wellcome Trust/United Kingdom

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