Acetylcholinesterase inhibition by flavonoids from Agrimonia pilosa

Molecules. 2007 Sep 3;12(9):2130-9. doi: 10.3390/12092130.

Abstract

In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism*
  • Agrimonia / chemistry*
  • Animals
  • Carbon Isotopes
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / isolation & purification*
  • Cholinesterase Inhibitors / pharmacology*
  • Electrophorus
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Protons
  • Spectrophotometry, Infrared

Substances

  • Carbon Isotopes
  • Cholinesterase Inhibitors
  • Flavonoids
  • Protons
  • Acetylcholinesterase