Science. 1976 Jun 11;192(4244):1134-7.

Oncogenic transformation of human embryo lung cells by human cytomegalovirus.

Abstract

Persistent infection of human embryo lung fibroblasts with a genital isolate of cytomegalovirus resulted in oncogenic transformation of these cells. Immunofluorescence techniques detected virus-specific antigens, while microcytotoxicity tests established that the transformed cells share a membrane antigen with hamster cells transformed by inactivated cytomegalovirus. The transformed human cells induced progressively growing tumors in weanling athymic nude mice.

PMID:: 179143; [PubMed - indexed for MEDLINE]

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Antigens, Viral

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