Osteopath Med Prim Care. 2007 Oct 2;1:14.

Treating anemia of chronic kidney disease in the primary care setting: cardiovascular outcomes and management recommendations.

Source

Section of Nephrology, Department of Medicine, West Virginia University Health Sciences Center, PO Box 9165, Morgantown, WV 26506, USA. rschmidt@hsc.wvu.edu.

Abstract

Anemia is an underrecognized but characteristic feature of chronic kidney disease (CKD), associated with significant cardiovascular morbidity, hospitalization, and mortality. Since their inception nearly two decades ago, erythropoiesis-stimulating agents (ESAs) have revolutionized the care of patients with renal anemia, and their use has been associated with improved quality of life and reduced hospitalizations, inpatient costs, and mortality. Hemoglobin targets >/=13 g/dL have been linked with adverse events in recent randomized trials, raising concerns over the proper hemoglobin range for ESA treatment. This review appraises observational and randomized studies of the outcomes of erythropoietic treatment and offers recommendations for managing renal anemia in the primary care setting.

PMID:: 17910755; [PubMed]
PMCID: PMC2147011

Free PMC Article

Images from this publication.See all images (2) Free text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Effects of the dose of erythropoiesis stimulating agents on cardiovascular events, quality of life, and health-related costs in hemodialysis patients: the clinical evaluation of the dose of erythropoietins (C.E. DOSE) trial protocol. [Trials. 2010]
Effects of the dose of erythropoiesis stimulating agents on cardiovascular events, quality of life, and health-related costs in hemodialysis patients: the clinical evaluation of the dose of erythropoietins (C.E. DOSE) trial protocol.
Strippoli GF, Clinical Evaluation of the DOse of Erythropoietins Study Group (C.E. DOSE). Trials. 2010 Jun 9; 11:70. Epub 2010 Jun 9.
2008 Japanese Society for Dialysis Therapy: guidelines for renal anemia in chronic kidney disease. [Ther Apher Dial. 2010]
2008 Japanese Society for Dialysis Therapy: guidelines for renal anemia in chronic kidney disease.
Tsubakihara Y, Nishi S, Akiba T, Hirakata H, Iseki K, Kubota M, Kuriyama S, Komatsu Y, Suzuki M, Nakai S, et al. Ther Apher Dial. 2010 Jun; 14(3):240-75.
Effect of erythropoiesis-stimulating agents on healthcare utilization, costs, and outcomes in chronic kidney disease. [Ann Pharmacother. 2007]
Effect of erythropoiesis-stimulating agents on healthcare utilization, costs, and outcomes in chronic kidney disease.
Maddux FW, Shetty S, del Aguila MA, Nelson MA, Murray BM. Ann Pharmacother. 2007 Nov; 41(11):1761-9. Epub 2007 Sep 25.
Review Optimizing anemia management in hospitalized patients with end-stage renal disease. [Ann Pharmacother. 2009]
Review Optimizing anemia management in hospitalized patients with end-stage renal disease.
Heung M, Mueller BA, Segal JH. Ann Pharmacother. 2009 Feb; 43(2):276-82. Epub 2009 Jan 13.
Review [Regarding the optimal hemoglobin target range in renal anemia]. [Med Klin (Munich). 2008]
Review [Regarding the optimal hemoglobin target range in renal anemia].
Maurin N. Med Klin (Munich). 2008 Sep 15; 103(9):633-7. Epub 2008 Sep 24.

See reviews... See all...

Cited by 3 PubMed Central articles

Key insights into present and future treatments of anaemia in CKD patients. [NDT Plus. 2009]
Key insights into present and future treatments of anaemia in CKD patients.
de Francisco AL. NDT Plus. 2009 Jan; 2(Suppl_1):i1-i2.
Future perspectives on treatment with erythropoiesis-stimulating agents in high-risk patients. [NDT Plus. 2009]
Future perspectives on treatment with erythropoiesis-stimulating agents in high-risk patients.
Anker SD, Toto R. NDT Plus. 2009 Jan; 2(Suppl_1):i3-i8.
Osteopathic Medicine and Primary Care looks forward to 2009. [Osteopath Med Prim Care. 2009]
Osteopathic Medicine and Primary Care looks forward to 2009.
Licciardone JC. Osteopath Med Prim Care. 2009 Feb 4; 3:2. Epub 2009 Feb 4.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Treating anemia of chronic kidney disease in the primary care setting: cardiovas...
Treating anemia of chronic kidney disease in the primary care setting: cardiovascular outcomes and management recommendations.
Osteopath Med Prim Care. 2007 Oct 2 ;1:14.

PubMed
Role of acetylcholine and polyspecific cation transporters in serotonin-induced ...
Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse.
Respir Res. 2006 Apr 12 ;7:65.

PubMed
The subplacenta of the red-rumped agouti (Dasyprocta leporina L).
The subplacenta of the red-rumped agouti (Dasyprocta leporina L).
Reprod Biol Endocrinol. 2006 Jun 1 ;4:31.

PubMed
Three decades (1978-2008) of Advanced Trauma Life Support (ATLS) practice revise...
Three decades (1978-2008) of Advanced Trauma Life Support (ATLS) practice revised and evidence revisited.
Scand J Trauma Resusc Emerg Med. 2008 Dec 18 ;16:19.

PubMed
DIALIGN-TX and multiple protein alignment using secondary structure information ...
DIALIGN-TX and multiple protein alignment using secondary structure information at GOBICS.
Nucleic Acids Res. 2010 Jul ;38(Web Server issue):W19-22. Epub 2010 May 23 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Treating anemia of chronic kidney disease in the primary care setting: cardiovascular outcomes and management recommendations.

Source

Abstract

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

Supplemental Content

Related citations

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information