Nature. 2007 Sep 27;449(7161):419-26.

Taking dendritic cells into medicine.

Source

The Rockefeller University, New York 10065, USA. steinma@mail.rockefeller.edu

Abstract

Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self. In the settings of infection and cancer, microbes and tumours can exploit DCs to evade immunity, but DCs also can generate resistance, a capacity that is readily enhanced with DC-targeted vaccines. During allergy, autoimmunity and transplant rejection, DCs instigate unwanted responses that cause disease, but, again, DCs can be harnessed to silence these conditions with novel therapies. Here we present some medical implications of DC biology that account for illness and provide opportunities for prevention and therapy.

PMID:: 17898760; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Review Dendritic cell subsets in health and disease. [Immunol Rev. 2007]
Review Dendritic cell subsets in health and disease.
Ueno H, Klechevsky E, Morita R, Aspord C, Cao T, Matsui T, Di Pucchio T, Connolly J, Fay JW, Pascual V, et al. Immunol Rev. 2007 Oct; 219:118-42.
Review Dendritic cells--why can they help and hurt us. [Exp Dermatol. 2009]
Review Dendritic cells--why can they help and hurt us.
Schäkel K. Exp Dermatol. 2009 Mar; 18(3):264-73. Epub 2009 Jan 24.
Review Manipulating dendritic cell biology for the active immunotherapy of cancer. [Blood. 2004]
Review Manipulating dendritic cell biology for the active immunotherapy of cancer.
O'Neill DW, Adams S, Bhardwaj N. Blood. 2004 Oct 15; 104(8):2235-46. Epub 2004 Jul 1.
Review Dendritic cells in the pathogenesis and treatment of human diseases: a Janus Bifrons? [Immunotherapy. 2011]
Review Dendritic cells in the pathogenesis and treatment of human diseases: a Janus Bifrons?
Cools N, Petrizzo A, Smits E, Buonaguro FM, Tornesello ML, Berneman Z, Buonaguro L. Immunotherapy. 2011 Oct; 3(10):1203-22.
Review Dendritic cell homeostasis. [Blood. 2009]
Review Dendritic cell homeostasis.
Merad M, Manz MG. Blood. 2009 Apr 9; 113(15):3418-27. Epub 2009 Jan 27.

See reviews... See all...

Cited by over 100 PubMed Central articles

The synovium in rheumatoid arthritis. [Open Rheumatol J. 2011]
The synovium in rheumatoid arthritis.
Hitchon CA, El-Gabalawy HS. Open Rheumatol J. 2011; 5:107-14. Epub 2011 Dec 30.
Dendritic cells take up and present antigens from viable and apoptotic polymorphonuclear leukocytes. [PLoS One. 2011]
Dendritic cells take up and present antigens from viable and apoptotic polymorphonuclear leukocytes.
Alfaro C, Suarez N, Oñate C, Perez-Gracia JL, Martinez-Forero I, Hervas-Stubbs S, Rodriguez I, Perez G, Bolaños E, Palazon A, et al. PLoS One. 2011; 6(12):e29300. Epub 2011 Dec 20.
The desmoplastic stroma plays an essential role in the accumulation and modulation of infiltrated immune cells in pancreatic adenocarcinoma. [Clin Dev Immunol. 2011]
The desmoplastic stroma plays an essential role in the accumulation and modulation of infiltrated immune cells in pancreatic adenocarcinoma.
Tjomsland V, Niklasson L, Sandström P, Borch K, Druid H, Bratthäll C, Messmer D, Larsson M, Spångeus A. Clin Dev Immunol. 2011; 2011:212810. Epub 2011 Dec 6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Taking dendritic cells into medicine.
Taking dendritic cells into medicine.
Nature. 2007 Sep 27 ;449(7161):419-26.

PubMed
Integrase inhibitor gains FDA approval.
Integrase inhibitor gains FDA approval.
Am J Health Syst Pharm. 2007 Nov 15 ;64(22):2310.

PubMed
Activation of an oncogenic microRNA cistron by provirus integration.
Activation of an oncogenic microRNA cistron by provirus integration.
Proc Natl Acad Sci U S A. 2006 Dec 5 ;103(49):18680-4. Epub 2006 Nov 22 .

PubMed
The discovery of the first human retrovirus: HTLV-1 and HTLV-2.
The discovery of the first human retrovirus: HTLV-1 and HTLV-2.
Retrovirology. 2005 Mar 2 ;2:17.

PubMed
Virus-host interactions: role of HIV proteins Vif, Tat, and Rev.
Virus-host interactions: role of HIV proteins Vif, Tat, and Rev.
AIDS. 2003 ;17 Suppl 4:S25-34.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: