Molecules. 2007 Mar 8;12(3):361-72.

An efficient synthesis of pyrazolo[3,4-b]quinolin-3-amine and benzo[b][1,8]naphthyridine derivatives.

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Chemistry Department, Faculty of Science, Helwan University, Ain-Helwan, Cairo, Egypt. y_elkholy@yahoo.com

Abstract

2-Oxo-4-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (10) reacted with hydrazine hydrate, phenylisothiocyanate or benzoyl chloride to give derivatives 12, 13 and 15, respectively. The latter two products were treated with hydrazine hydrate to afford pyrozole[3,4-b]quinolines derivatives 14 and 16, respectively. Compound 10 also reacted with acetonitrile dimer or malononitrile dimer to yield benzo[b][1,8]-naphthyridine derivatives. A single crystal X-ray crystallographic analysis was performed on compound 10, confirming its structure.

PMID:: 17851395; [PubMed - indexed for MEDLINE]

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An efficient synthesis of pyrazolo[3,4-b]quinolin-3-amine and benzo[b][1,8]napht...
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An efficient synthesis of pyrazolo[3,4-b]quinolin-3-amine and benzo[b][1,8]naphthyridine derivatives.

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