Int MS J. 2007 Jun;14(2):41-7.

Human herpesviruses in MS.

Source

Institute of Medical Microbiology and Immunology, University of Aarhus, Denmark. tc@microbiology.au.dk

Abstract

Environmental factors operate on a background of genetic susceptibility in MS pathogenesis; the human herpesviruses (HHV) are likely candidates for such factors. HHV share a number of properties: they are almost ubiquitous, they are highly prevalent worldwide, they all cause latent infections and they are capable of reactivation. Epstein Barr virus (EBV), HHV-6A and varicella zoster virus (VZV) are consistently linked with MS, particularly with respect to epidemiology, antibody responses in serum (EBV) and cerebrospinal fluid (EBV and HHV-6A), and with MS exacerbations that are associated with viral reactivation (VZV, HHV-6A and EBV). HHV have the potential for a causal role in MS--they may be key players in the disease process--and this role could be mediated through several direct or indirect mechanisms.

PMID:: 17686342; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Other Literature Sources

Medical

Multiple Sclerosis - MedlinePlus Health Information

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Review The role of EBV in MS pathogenesis. [Int MS J. 2006]
Review The role of EBV in MS pathogenesis.
Christensen T. Int MS J. 2006 May; 13(2):52-7.
Review [Prevention and therapy of herpesvirus infections]. [Zentralbl Bakteriol Mikrobiol ...]
Review [Prevention and therapy of herpesvirus infections].
Abb J. Zentralbl Bakteriol Mikrobiol Hyg B. 1985 Feb; 180(2-3):107-20.
Review [Infectious agents in the pathogenesis of multiple sclerosis]. [Przegl Epidemiol. 2006]
Review [Infectious agents in the pathogenesis of multiple sclerosis].
Szczuciński A, Losy J. Przegl Epidemiol. 2006; 60 Suppl 1:160-5.
Altered antibody pattern to Epstein-Barr virus but not to other herpesviruses in multiple sclerosis: a population based case-control study from western Norway. [J Neurol Neurosurg Psychiatry....]
Altered antibody pattern to Epstein-Barr virus but not to other herpesviruses in multiple sclerosis: a population based case-control study from western Norway.
Myhr KM, Riise T, Barrett-Connor E, Myrmel H, Vedeler C, Grønning M, Kalvenes MB, Nyland H. J Neurol Neurosurg Psychiatry. 1998 Apr; 64(4):539-42.
[Human herpesvirus 6 (HHV-6): incidence in healthy blood donors and in patients with acute infections caused by other herpes viruses]. [Wien Klin Wochenschr. 1989]
[Human herpesvirus 6 (HHV-6): incidence in healthy blood donors and in patients with acute infections caused by other herpes viruses].
Larcher C, Huemer HP, Hönlinger M, Margreiter R, Dierich MP. Wien Klin Wochenschr. 1989 Jun 23; 101(13):448-50.

See reviews... See all...

Cited by 6 PubMed Central articles

The effect of mouse strain on herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS). [Herpesviridae. 2012]
The effect of mouse strain on herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS).
Kastrukoff LF, Lau AS, Thomas EE. Herpesviridae. 2012 Mar 26; 3:4. Epub 2012 Mar 26.
B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity. [Retrovirology. 2009]
B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity.
Brudek T, Christensen T, Aagaard L, Petersen T, Hansen HJ, Møller-Larsen A. Retrovirology. 2009 Nov 16; 6:104. Epub 2009 Nov 16.
HLA class I molecules reflect an altered host proteome after influenza virus infection. [Hum Immunol. 2010]
HLA class I molecules reflect an altered host proteome after influenza virus infection.
Wahl A, Schafer F, Bardet W, Hildebrand WH. Hum Immunol. 2010 Jan; 71(1):14-22.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Human herpesviruses in MS.
Human herpesviruses in MS.
Int MS J. 2007 Jun ;14(2):41-7.

PubMed
p53 transgenic mice: accelerated erythroleukemia induction by Friend virus.
p53 transgenic mice: accelerated erythroleukemia induction by Friend virus.
Oncogene. 1991 Dec ;6(12):2197-201.

PubMed
Regulatory mechanisms of microRNAs involvement in cancer.
Regulatory mechanisms of microRNAs involvement in cancer.
Expert Opin Biol Ther. 2007 Jul ;7(7):1009-19.

PubMed
Characterization of the type and group specificities of the immune response in m...
Characterization of the type and group specificities of the immune response in mice to murine leukemia viruses.
J Virol. 1976 Apr ;18(1):124-31.

PubMed
Regulation of HIV-1 latency by T-cell activation.
Regulation of HIV-1 latency by T-cell activation.
Cytokine. 2007 Jul ;39(1):63-74. Epub 2007 Jul 20 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: