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    J Rheumatol. 1991 Oct;18(10):1621-2.

    Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.

    Source

    2nd Department of Internal Medicine, University of Vienna, Austria.

    Abstract

    The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis. In addition to glomerulonephritis and a butterfly rash, previously negative tests for antinuclear, anti-dsDNA and anti-Sm antibodies became positive. We assume that rIFN-gamma induced the de novo development of SLE in our patient.

    PMID:
    1765991
    [PubMed - indexed for MEDLINE]

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