C R Acad Sci III. 1991;313(11):481-7.

Stability of CD4/CD8 ratios in man: new correlation between CD4/CD8 profiles and iron overload in idiopathic haemochromatosis patients.

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Institut Abel Salazar des Sciences biomédicales, Porto, Portugal.

Abstract

The proportions of CD4+, CD8+ cells were determined in peripheral blood samples obtained from 27 patients with idiopathic haemochromatosis and 67 healthy controls. Samples from the patients were obtained at the start of therapy and at intervals during intensive phlebotomy treatment in which 400 ml of blood are removed each week for 6 months to 2 years. Patients varied in their CD4/CD8 ratios from 0.8 to 4.2. An individual's CD4/CD8 ratio, however, remained unaffected by the repeated removal of large volumes of blood by phlebotomy confirming the existence of a homeostatic regulation of the relative numbers of the two major peripheral T cell pools in man. Follow-up of iron reentry into the transferrin pool at the end of the intensive phlebotomy treatment indicates that the relative proportion of circulating CD4/CD8 cells is critically related to the regulation of iron absorption.

PMID:: 1760751; [PubMed - indexed for MEDLINE]

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Related citations in PubMed

Haemochromatosis as a window into the study of the immunological system: a novel correlation between CD8+ lymphocytes and iron overload. [Eur J Haematol. 1994]
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Cited by 6 PubMed Central articles

A new 500 kb haplotype associated with high CD8+ T-lymphocyte numbers predicts a less severe expression of hereditary hemochromatosis. [BMC Med Genet. 2008]
A new 500 kb haplotype associated with high CD8+ T-lymphocyte numbers predicts a less severe expression of hereditary hemochromatosis.
Cruz E, Whittington C, Krikler SH, Mascarenhas C, Lacerda R, Vieira J, Porto G. BMC Med Genet. 2008 Nov 6; 9:97. Epub 2008 Nov 6.
A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload. [BMC Med Genet. 2006]
A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload.
Cruz E, Vieira J, Almeida S, Lacerda R, Gartner A, Cardoso CS, Alves H, Porto G. BMC Med Genet. 2006 Mar 1; 7:16. Epub 2006 Mar 1.
Total blood lymphocyte counts in hemochromatosis probands with HFE C282Y homozygosity: relationship to severity of iron overload and HLA-A and -B alleles and haplotypes. [BMC Blood Disord. 2005]
Total blood lymphocyte counts in hemochromatosis probands with HFE C282Y homozygosity: relationship to severity of iron overload and HLA-A and -B alleles and haplotypes.
Barton JC, Wiener HW, Acton RT, Go RC. BMC Blood Disord. 2005 Jul 25; 5:5. Epub 2005 Jul 25.

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