J Clin Invest. 1991 Dec;88(6):1785-92.

Role of oxidized low density lipoprotein in atherogenesis.

Source

Department of Medicine, University of California, San Diego, La Jolla 92093.

Abstract

Evidence to support an important role of oxidative modification in mediating the atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-LDL or products of Ox-LDL can affect many components of the atherogenic process, including vasomotor properties and thrombosis, as well as lesion initiation and progression itself. These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.

PMID:: 1752940; [PubMed - indexed for MEDLINE]
PMCID:: PMC295745

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Lipoproteins, LDL

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Review Low density lipoprotein oxidation and atherogenesis: from experimental models to clinical studies. [G Ital Cardiol. 1997]
Review Low density lipoprotein oxidation and atherogenesis: from experimental models to clinical studies.
Napoli C. G Ital Cardiol. 1997 Dec; 27(12):1302-14.
Review The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosis. [Annu Rev Med. 1992]
Review The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosis.
Parthasarathy S, Steinberg D, Witztum JL. Annu Rev Med. 1992; 43:219-25.
Review The role of oxidized low density lipoprotein in atherogenesis. [J Nutr. 1996]
Review The role of oxidized low density lipoprotein in atherogenesis.
Jialal I, Devaraj S. J Nutr. 1996 Apr; 126(4 Suppl):1053S-7S.
Review The oxidative modification hypothesis of atherosclerosis: the comparison of atherogenic effects on oxidized LDL and remnant lipoproteins in plasma. [Clin Chim Acta. 2006]
Review The oxidative modification hypothesis of atherosclerosis: the comparison of atherogenic effects on oxidized LDL and remnant lipoproteins in plasma.
Nakajima K, Nakano T, Tanaka A. Clin Chim Acta. 2006 May; 367(1-2):36-47. Epub 2006 Jan 30.
The effects of lipid-lowering therapy on low-density lipoprotein auto-antibodies: relationship with low-density lipoprotein oxidation and plasma total antioxidant status. [Coron Artery Dis. 2002]
The effects of lipid-lowering therapy on low-density lipoprotein auto-antibodies: relationship with low-density lipoprotein oxidation and plasma total antioxidant status.
Orem C, Orem A, Uydu HA, Celik S, Erdöl C, Kural BV. Coron Artery Dis. 2002 Feb; 13(1):65-71.

See reviews... See all...

Cited by over 100 PubMed Central articles

Serum Lipid, Lipoprotein and Oxidatively Modified Low Density Lipoprotein Levels in Active or Inactive Patients with Behçet's Disease. [Indian J Dermatol. 2012]
Serum Lipid, Lipoprotein and Oxidatively Modified Low Density Lipoprotein Levels in Active or Inactive Patients with Behçet's Disease.
Cimen F, Yildirmak ST, Ergen A, Cakmak M, Dogan S, Yenice N, Sezgin F. Indian J Dermatol. 2012 Mar; 57(2):97-101.
Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. [J Clin Invest. 2012]
Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin.
Owens AP 3rd, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, et al. J Clin Invest. 2012 Feb 1; 122(2):558-68. Epub 2012 Jan 3.
Primary human monocyte differentiation regulated by Nigella sativa pressed oil. [Lipids Health Dis. 2011]
Primary human monocyte differentiation regulated by Nigella sativa pressed oil.
Mat MC, Mohamed AS, Hamid SS. Lipids Health Dis. 2011 Nov 21; 10:216. Epub 2011 Nov 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Role of oxidized low density lipoprotein in atherogenesis.
Role of oxidized low density lipoprotein in atherogenesis.
J Clin Invest. 1991 Dec ;88(6):1785-92.

PubMed
Long-term effect of dietary {alpha}-linolenic acid or decosahexaenoic acid on in...
Long-term effect of dietary {alpha}-linolenic acid or decosahexaenoic acid on incorporation of decosahexaenoic acid in membranes and its influence on rat heart in vivo.
Am J Physiol Heart Circ Physiol. 2007 Oct ;293(4):H2296-304. Epub 2007 May 25 .

PubMed
Islet function in offspring of mothers on low-protein diet during gestation.
Islet function in offspring of mothers on low-protein diet during gestation.
Diabetes. 1991 Dec ;40 Suppl 2:115-20.

PubMed
Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariff...
Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa.
Fitoterapia. 2007 Jun ;78(4):292-7. Epub 2007 Apr 11 .

PubMed
Arterial metabolism in primates.
Arterial metabolism in primates.
Primates Med. 1976 ;9:145-223.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: