Eur J Immunol. 2007 Jun;37(6):1427-30.

Activities of erythropoietin on tumors: an immunological perspective.

Source

Laboratory of Neuroimmunology, Mario Negri Institute, Milan, Italy. pietro.ghezzi@libero.it

Abstract

There is a growing interest in the non-erythropoietic, tissue-protective and restorative actions of erythropoietin (EPO). While studies in this field have indicated that EPO can ameliorate chemotherapy-induced peripheral neuropathy and cardiotoxicity, the issue whether EPO can positively or negatively affect cancer patients is a hot one. In this debate, many activities of EPO are being considered, including tissue/neuroprotection, angiogenesis, anti-inflammatory activity, growth promotion, and inhibition of apoptosis. However, few studies have explored the interactions of EPO with the immune system. A study in this issue of the European Journal of Immunology by Katz et al. adds one new piece to the puzzle by showing that EPO can stimulate B cell-mediated immunity.

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Eur J Immunol. 2007 Jun;37(6):1584-93.

PMID:: 17506033; [PubMed - indexed for MEDLINE]

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