Fitoterapia. 2007 Jun;78(4):292-7. Epub 2007 Apr 11.

Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa.

Mojiminiyi FB, Dikko M, Muhammad BY, Ojobor PD, Ajagbonna OP, Okolo RU, Igbokwe UV, Mojiminiyi UE, Fagbemi MA, Bello SO, Anga TJ.

Source

Department of Physiology, Usman Danfodio University, Sokoto, Nigeria. mojiminiyi@yahoo.co.uk

Abstract

The present study was designed to investigate the efficacy of an aqueous calyx extract of Hibiscus sabdariffa (HS) in two forms of experimental hypertension: salt-induced and L-NAME (N(omega)-L-arginine methyl ester)-induced and in normotensive controls. The blood pressure and heart rate fell dose-dependently in both the hypertensive and normotensive rats after intravenous injection of 1-125 mg/kg of HS, suggesting that HS possesses anti-hypertensive, hypotensive and negative chronotropic effects. The fall in mean arterial pressure was significantly pronounced in the hypertensive rats (salt-induced: 94.4+/-8.6 mm Hg; L-NAME-induced: 136.5+/-10.3 mm Hg) than in the normotensive controls (50.2+/-5.1 mm Hg; P<0.05).

PMID:: 17482378; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Molecular Biology Databases

SODIUM CHLORIDE - HSDB

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Possible mechanisms of action of the neutral extract from Bidens pilosa L. leaves on the cardiovascular system of anaesthetized rats. [Phytother Res. 2003]
Possible mechanisms of action of the neutral extract from Bidens pilosa L. leaves on the cardiovascular system of anaesthetized rats.
Dimo T, Nguelefack TB, Tan PV, Yewah MP, Dongo E, Rakotonirina SV, Kamanyi A, Bopelet M. Phytother Res. 2003 Dec; 17(10):1135-9.
Solanum indicum ssp. distichum extract is effective against L-NAME-induced hypertension in rats. [Fundam Clin Pharmacol. 2008]
Solanum indicum ssp. distichum extract is effective against L-NAME-induced hypertension in rats.
Bahgat A, Abdel-Aziz H, Raafat M, Mahdy A, El-Khatib AS, Ismail A, Khayyal MT. Fundam Clin Pharmacol. 2008 Dec; 22(6):693-9.
Antihypertensive effect of a standardized aqueous extract of Cecropia glaziovii Sneth in rats: an in vivo approach to the hypotensive mechanism. [Phytomedicine. 2007]
Antihypertensive effect of a standardized aqueous extract of Cecropia glaziovii Sneth in rats: an in vivo approach to the hypotensive mechanism.
Lima-Landman MT, Borges AC, Cysneiros RM, De Lima TC, Souccar C, Lapa AJ. Phytomedicine. 2007 May; 14(5):314-20. Epub 2007 Apr 18.
Review Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review. [Phytother Res. 2005]
Review Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review.
Ali BH, Al Wabel N, Blunden G. Phytother Res. 2005 May; 19(5):369-75.
Review Antihypertensive effects of the flavonoid quercetin. [Pharmacol Rep. 2009]
Review Antihypertensive effects of the flavonoid quercetin.
Perez-Vizcaino F, Duarte J, Jimenez R, Santos-Buelga C, Osuna A. Pharmacol Rep. 2009 Jan-Feb; 61(1):67-75.

See reviews... See all...

Cited by 4 PubMed Central articles

Ethnopharmacology of medicinal plants of the pantanal region (mato grosso, Brazil). [Evid Based Complement Alternat...]
Ethnopharmacology of medicinal plants of the pantanal region (mato grosso, Brazil).
Bieski IG, Rios Santos F, de Oliveira RM, Espinosa MM, Macedo M, Albuquerque UP, de Oliveira Martins DT. Evid Based Complement Alternat Med. 2012; 2012:272749. Epub 2012 Feb 26.
Role of natural herbs in the treatment of hypertension. [Pharmacogn Rev. 2011]
Role of natural herbs in the treatment of hypertension.
Tabassum N, Ahmad F. Pharmacogn Rev. 2011 Jan; 5(9):30-40.
Survey on medicinal plants and spices used in Beni-Sueif, Upper Egypt. [J Ethnobiol Ethnomed. 2011]
Survey on medicinal plants and spices used in Beni-Sueif, Upper Egypt.
AbouZid SF, Mohamed AA. J Ethnobiol Ethnomed. 2011 Jun 27; 7:18. Epub 2011 Jun 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariff...
Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa.
Fitoterapia. 2007 Jun ;78(4):292-7. Epub 2007 Apr 11 .

PubMed
Arterial metabolism in primates.
Arterial metabolism in primates.
Primates Med. 1976 ;9:145-223.

PubMed
Leucine and calcium regulate fat metabolism and energy partitioning in murine ad...
Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells.
Lipids. 2007 Apr ;42(4):297-305. Epub 2007 Feb 20 .

PubMed
Brefeldin A: insights into the control of membrane traffic and organelle structu...
Brefeldin A: insights into the control of membrane traffic and organelle structure.
J Cell Biol. 1992 Mar ;116(5):1071-80.

PubMed
Prevention of prostate cancer through custom tailoring of chemopreventive regime...
Prevention of prostate cancer through custom tailoring of chemopreventive regimen.
Chem Biol Interact. 2008 Jan 30 ;171(2):122-32. Epub 2007 Mar 12 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information