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    Chem Biol Interact. 1977 Apr;17(1):61-7.

    Aurinetricarboxylic acid: a potent inhibitor of glucose-6-phosphate dehydrogenase.

    Abstract

    Inhibition by aurinetricarboxylic acid (ATA) of glucose-6-phosphate (G6P) dehydrogenase was "competitive" with respect to G6P and "mixed type" with respect to NADP+. Inhibited enzyme bound two molecules of ATA. Kinetic constants, Km, Ki at varying pH suggested possible binding of the inhibitor by the sulfhydryl of the enzyme; of the several enzymes tested only milk xanthine oxidase and G6P dehydrogenase from bovine adrenal was inhibited by ATA.

    PMID:
    17474
    [PubMed - indexed for MEDLINE]

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