Arch Otolaryngol Head Neck Surg. 1991 Nov;117(11):1265-8.

The effect of postoperative radiation therapy on pharyngoesophageal reconstruction with free jejunal interposition.

Petruzzelli GJ, Johnson JT, Myers EN, Shestak K, Jones NF, Cano E, deVries EJ, Wagner R.

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Department of Otolaryngology, University of Pittsburgh, School of Medicine, PA.

Abstract

Free tissue transfer of a jejunal segment was undertaken for laryngopharyngoesophageal reconstruction in 20 patients who received postoperative irradiation therapy. Treatment consisted of 1.8- to 2-Gy-fractions, the average total dose was 55.57 Gy (range, 40 to 66 Gy). Anastomotic strictures (six) were encountered early in the series and associated with stapled anastomoses. Hand-sewing the jejunoesophagostomy eliminated the problem. Enteric cutaneous fistula, bowel necrosis, and hemorrhagic enteritis were not observed. We conclude that the application of postoperative irradiation therapy to patients requiring jejunal interposition grafts is feasible.

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