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    Retrovirology. 2007 Jan 25;4:5.

    Retroviral activation of the mir-106a microRNA cistron in T lymphoma.

    Lum AM, Wang BB, Li L, Channa N, Bartha G, Wabl M.

    Source

    Picobella, L.L.C., Burlingame, CA, 94010, USA. amy@picobella.com

    Abstract

    Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron. In tumors containing an integration, the primary transcript encoding the mir-106a cistron was overexpressed five to 20-fold compared with that of control tumors; concomitantly, the mature mir-106a and mir-363 microRNAs were highly overexpressed as well. These findings suggest the mir-106a cistron plays an important role in T cell tumorigenesis.

    PMID:
    17442096
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC1794537
    Free PMC Article

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