AIDS. 2007 Apr 23;21(7):869-71.

Elevated plasma levels of high mobility group box protein 1 in patients with HIV-1 infection.

Source

Divisions of Clinical Virology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Abstract

High mobility group box protein 1 (HMGB1) is a potent proinflammatory mediator. It has a dichotomic effect on HIV-1 replication in vitro but its role in vivo is unknown. Here we report the novel finding that plasma HMGB1 levels are elevated in HIV-1-infected patients, with the highest concentrations in patients with clinical complications. HMGB1 is likely to contribute to immunoactivation in HIV-1 infection in vivo.

PMID:: 17415043; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

MeSH Terms

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HMGB1 Protein

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