Arthritis Res Ther. 2007;9(2):102.

T cells and post menopausal osteoporosis in murine models.

Source

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. roberto.pacifici@emory.edu

Abstract

Estrogen deficiency is one of the most frequent causes of osteoporosis in women and a possible cause of bone loss in men. But the mechanism involved remains largely unknown. Estrogen deficiency leads to an increase in the immune function, which culminates in an increased production of tumor necrosis factor (TNF) by activated T cells. TNF increases osteoclast formation and bone resorption both directly and by augmenting the sensitivity of maturing osteoclasts to the essential osteoclastogenic factor RANKL (the RANK ligand). Increased T cell production of TNF is induced by estrogen deficiency via a complex mechanism mediated by antigen presenting cells and the cytokines IFNgamma, IL-7 and transforming growth factor-beta. The experimental evidence that suggests that estrogen prevents bone loss by regulating T cell function and the interactions between immune cells and bone is reviewed here.

PMID:: 17349065; [PubMed - indexed for MEDLINE]
PMCID: PMC1906793

Free PMC Article

Images from this publication.See all images (1) Free text

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Review Estrogen regulation of immune cell bone interactions. [Ann N Y Acad Sci. 2006]
Review Estrogen regulation of immune cell bone interactions.
Weitzmann MN, Pacifici R. Ann N Y Acad Sci. 2006 Apr; 1068:256-74.
Review The role of T lymphocytes in bone metabolism. [Immunol Rev. 2005]
Review The role of T lymphocytes in bone metabolism.
Weitzmann MN, Pacifici R. Immunol Rev. 2005 Dec; 208:154-68.
Review Post-menopausal osteoporosis: is it an autoimmune disease? [J Endocrinol Invest. 2005]
Review Post-menopausal osteoporosis: is it an autoimmune disease?
Ambrogini E, Toraldo G, Marcocci C. J Endocrinol Invest. 2005; 28(10 Suppl):43-7.
Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis. [Bone. 2008]
Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis.
D'Amelio P, Grimaldi A, Di Bella S, Brianza SZ, Cristofaro MA, Tamone C, Giribaldi G, Ulliers D, Pescarmona GP, Isaia G. Bone. 2008 Jul; 43(1):92-100. Epub 2008 Mar 7.
Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo. [Proc Natl Acad Sci U S A. 2001]
Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo.
Roggia C, Gao Y, Cenci S, Weitzmann MN, Toraldo G, Isaia G, Pacifici R. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13960-5.

See reviews... See all...

Cited by 1 PubMed Central article

Daidzein prevents the increase in CD4+CD28null T cells and B lymphopoesis in ovariectomized mice: a key mechanism for anti-osteoclastogenic effect. [PLoS One. 2011]
Daidzein prevents the increase in CD4+CD28null T cells and B lymphopoesis in ovariectomized mice: a key mechanism for anti-osteoclastogenic effect.
Tyagi AM, Srivastava K, Sharan K, Yadav D, Maurya R, Singh D. PLoS One. 2011; 6(6):e21216. Epub 2011 Jun 22.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

T cells and post menopausal osteoporosis in murine models.
T cells and post menopausal osteoporosis in murine models.
Arthritis Res Ther. 2007 ;9(2):102.

PubMed
Tracking the polio virus down the Congo River: a case study on the use of Google...
Tracking the polio virus down the Congo River: a case study on the use of Google Earth in public health planning and mapping.
Int J Health Geogr. 2009 Jan 22 ;8:4.

PubMed
Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and ...
Stereotactic, single-dose irradiation of stage I non-small cell lung cancer and lung metastases.
Radiat Oncol. 2006 Aug 20 ;1:30.

PubMed
TGFbeta1 signaling via alphaVbeta6 integrin.
TGFbeta1 signaling via alphaVbeta6 integrin.
Mol Cancer. 2003 Aug 7 ;2:28.

PubMed
Feasibility and long-term results of focused radioguided parathyroidectomy using...
Feasibility and long-term results of focused radioguided parathyroidectomy using a "low" 37 MBq (1 mCi) 99mTc-sestamibi protocol.
Int Semin Surg Oncol. 2006 Sep 15 ;3:30.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

T cells and post menopausal osteoporosis in murine models.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Libraries

Supplemental Content

Related citations

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information