J Mammary Gland Biol Neoplasia. 2007 Mar;12(1):3-13.

The beginning of the end: death signaling in early involution.

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Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. fob20@cam.ac.uk

Abstract

Mammary gland involution occurs in two distinct phases: an early, reversible phase, involving extensive apoptosis of the secretory alveolar epithelium without major changes in gland architecture, and a later, irreversible phase, involving remodelling of the gland to its pre-pregnancy state. Multiple signalling pathways are known to be important during early involution, however the precise triggers remain elusive. This review summarizes the roles of a number of key pathways (NF-kappaB, PI(3)K, Stat3, and TGFbeta) in the first phase of involution.

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Cited by 6 PubMed Central articles

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