Biochem Biophys Res Commun. 1992 Jan 15;182(1):27-33.

The N-terminal segment of protein AA determines its fibrillogenic property.

Westermark GT, Engström U, Westermark P.

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Department of Pathology, University of Linköping, Sweden.

Abstract

The amyloid fibril protein AA consists of a varying long N-terminal part of the precursor protein serum AA. By using synthetic peptides corresponding to human and murine protein AA segments and cyanogen bromide fragments of human protein AA, we show evidence that the amyloidogenic part of the molecule is the first 10-15 amino acid long segment. Amino acid substitutions in this part of the molecule may explain why only one of the two mouse SAA isoforms is amyloidogenic.

PMID:: 1731787; [PubMed - indexed for MEDLINE]

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