Exp Parasitol. 1992 Feb;74(1):11-9.

Localisation of hypoxanthine phosphoribosyl transferase in the malaria parasite Plasmodium falciparum.

Shahabuddin M, Günther K, Lingelbach K, Aikawa M, Schreiber M, Ridley RG, Scaife JG.

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Institute of Cell and Molecular Biology, University of Edinburgh, Scotland.

Abstract

The enzyme hypoxanthine phosphoribosyl transferase of the human malaria parasite Plasmodium falciparum has been located in parasites and parasite-infected erythrocytes by antibody probing. The probe was a polyclonal rabbit antiserum made against the parasite enzyme made in Escherichia coli. The enzyme is associated with membrane-bound compartments in merozoites and asexual blood parasites. In particular, indirect immunofluorescence studies reveal the enzyme localized in vesicle-like structures within the cytoplasm of the infected erythrocyte. This is the first time a P. falciparum protein of defined metabolic function has been tracked to a site outside the parasite cytosol. Studies on the targeting of the enzyme using a cell-free system suggests that the protein reaches its destination via a route different from the normal secretory pathway.

PMID:: 1730267; [PubMed - indexed for MEDLINE]

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