Autoimmun Rev. 2007 Jan;6(3):119-25. Epub 2006 Sep 11.

Clinical and biological aspects of anti-P-ribosomal protein autoantibodies.

Source

Division of Clinical Immunology and Allergy, Bnai-Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.

Abstract

Among the many clinical manifestations of systemic lupus erythematosus (SLE), central nervous system (CNS) involvement is of a prognostic importance. In this respect, anti-ribosomal P protein antibodies were shown by many to occur in association with SLE neuropsychiatric manifestations, mainly psychosis. The prevalence of anti-P antibodies was strongly related to disease activity wherein disease remission was associated with the disappearance of these antibodies. In addition to its association with CNS involvement, the occurrence of liver and kidney disease in SLE patients with anti-P antibodies was widely reported. Anti-P antibodies are able to bind T cells, monocytes, neurons and hepatocytes thereby enhancing the production of pro-inflammatory cytokines and both CNS and liver damage. Similar to the ability of anti-dsDNA antibodies, anti-P antibodies were shown to penetrate into living cells, leading to cell dysfunctions such as cell apoptosis. These biological aspects may play an important role in the pathogenesis of SLE.

PMID:: 17289545; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Lupus - MedlinePlus Health Information

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Association of psychiatric manifestations with antibodies to ribosomal P proteins in systemic lupus erythematosus. [Am J Med. 1991]
Association of psychiatric manifestations with antibodies to ribosomal P proteins in systemic lupus erythematosus.
Schneebaum AB, Singleton JD, West SG, Blodgett JK, Allen LG, Cheronis JC, Kotzin BL. Am J Med. 1991 Jan; 90(1):54-62.
Restricted specificity of anti-ribosomal P antibodies to SLE patients in Israel. [Clin Exp Rheumatol. 2006]
Restricted specificity of anti-ribosomal P antibodies to SLE patients in Israel.
Shovman O, Zandman-Goddard G, Gilburd B, Blank M, Ehrenfeld M, Bardechevski S, Stojanovich L, Langevitz P, Shoenfeld Y. Clin Exp Rheumatol. 2006 Nov-Dec; 24(6):694-7.
Correlation of antibodies to ribosomal P protein with psychosis in patients with systemic lupus erythematosus. [Ann Rheum Dis. 1992]
Correlation of antibodies to ribosomal P protein with psychosis in patients with systemic lupus erythematosus.
Nojima Y, Minota S, Yamada A, Takaku F, Aotsuka S, Yokohari R. Ann Rheum Dis. 1992 Sep; 51(9):1053-5.
Review Anti-P antibodies and neuropsychiatric lupus erythematosus. [Ann N Y Acad Sci. 1997]
Review Anti-P antibodies and neuropsychiatric lupus erythematosus.
Georgescu L, Mevorach D, Arnett FC, Reveille JD, Elkon KB. Ann N Y Acad Sci. 1997 Aug 14; 823:263-9.
Review Autoantibodies to the ribosomal P proteins in systemic lupus erythematosus. [Clin Exp Med. 2006]
Review Autoantibodies to the ribosomal P proteins in systemic lupus erythematosus.
Reichlin M. Clin Exp Med. 2006 Jun; 6(2):49-52.

See reviews... See all...

Cited by 6 PubMed Central articles

A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children. [J Neuroinflammation. 2012]
A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children.
Al-Ayadhi LY, Mostafa GA. J Neuroinflammation. 2012 Mar 16; 9:54. Epub 2012 Mar 16.
Neuropsychiatric lupus and association with cerebrospinal fluid immunoglobulins: a pilot study. [Isr Med Assoc J. 2009]
Neuropsychiatric lupus and association with cerebrospinal fluid immunoglobulins: a pilot study.
Stojanovich L, Smiljanich-Miljkovich D, Omdal R, Sakic B. Isr Med Assoc J. 2009 Jun; 11(6):359-62.
Review Neurocognitive impairment in children and adolescents with systemic lupus erythematosus. [Nat Clin Pract Rheumatol. 2009]
Review Neurocognitive impairment in children and adolescents with systemic lupus erythematosus.
Levy DM, Ardoin SP, Schanberg LE. Nat Clin Pract Rheumatol. 2009 Feb; 5(2):106-14.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Clinical and biological aspects of anti-P-ribosomal protein autoantibodies.
Clinical and biological aspects of anti-P-ribosomal protein autoantibodies.
Autoimmun Rev. 2007 Jan ;6(3):119-25. Epub 2006 Sep 11 .

PubMed
Factors influencing publication of research results. Follow-up of applications s...
Factors influencing publication of research results. Follow-up of applications submitted to two institutional review boards.
JAMA. 1992 Jan 15 ;267(3):374-8.

PubMed
Familial Mediterranean fever successfully treated with etanercept.
Familial Mediterranean fever successfully treated with etanercept.
J Clin Rheumatol. 2007 Feb ;13(1):38-40.

PubMed
Thiol-containing compounds inhibit the production of monocyte/macrophage-derived...
Thiol-containing compounds inhibit the production of monocyte/macrophage-derived angiogenic activity.
Agents Actions. 1991 Nov ;34(3-4):350-7.

PubMed
Hepatosplenic T cell lymphoma associated with infliximab use in young patients t...
Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease.
J Pediatr Gastroenterol Nutr. 2007 Feb ;44(2):265-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: