Retrovirology. 2007 Feb 2;4:9.

Methylation: a regulator of HIV-1 replication?

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Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, the National Institutes of Health, Bethesda, Maryland 20892, USA. vyedavalli@mail.nih.gov

Abstract

Recent characterizations of methyl transferases as regulators of cellular processes have spurred investigations into how methylation events might influence the HIV-1 life cycle. Emerging evidence suggests that protein-methylation can positively and negatively regulate HIV-1 replication. How DNA- and RNA- methylation might impact HIV-1 is also discussed.

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