J Pediatr Gastroenterol Nutr. 2007 Feb;44(2):265-7.

Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease.

Mackey AC, Green L, Liang LC, Dinndorf P, Avigan M.

Source

Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, MD, USA.

Abstract

Hepatosplenic T cell lymphoma (HSTCL) are rare cancers ( approximately 100 published cases worldwide) and comprise 5% of peripheral T cell lymphomas. As of October 5, 2006, the FDA's Adverse Event Reporting System has received 8 cases of HSTCL in young patients using infliximab, a tumor necrosis factor-alpha blocking agent, to treat inflammatory bowel disease (6 of the 8 cases had a fatal outcome). All 8 patients were receiving concomitant immunosuppressant therapy (eg, azathioprine, prednisone). It has not been established that infliximab had an exclusive or primary role in the pathogenesis of these HSTCL cases; however, it appears that patients using this product may be at greater risk for developing this rare lymphoma.

Comment in

J Pediatr Gastroenterol Nutr. 2009 Mar;48(3):386-8.

PMID:: 17255842; [PubMed - indexed for MEDLINE]

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