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    Cell. 2007 Jan 26;128(2):233-4.

    Oncogene-induced senescence pathways weave an intricate tapestry.

    Source

    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., Berkeley, CA 94720, USA. p_yaswen@lbl.gov

    Abstract

    The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.

    PMID:
    17254959
    [PubMed - indexed for MEDLINE]

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