Crit Care. 2007;11(1):104.

The origin and interpretation of hyperlactataemia during low oxygen delivery states.

Source

Chelsea & Westminster Hospital, Imperial College London, London, UK. j.m.handy@imperial.ac.uk

Abstract

The origin of hyperlactataemia during critical illness is complex but its presence can provide an indicator of inadequate tissue oxygen delivery. Cardiopulmonary bypass (CPB) represents a unique situation where systemic oxygen delivery can be directly measured and controlled. In the previous issue of Critical Care, Ranucci and colleagues use this phenomenon to identify independent variables associated with the development of hyperlactataemia during CPB. In doing so they highlight the complexity of interpreting hyperlactataemia during critical illness and provide further evidence of its association with worse postoperative morbidity.

Comment on

Crit Care. 2006;10(6):R167.

PMID:: 17254315; [PubMed - indexed for MEDLINE]
PMCID: PMC2151904

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Comment

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Alternate explanation for the increasing oxygen consumption and lactatemia after surgery with hypothermic cardiopulmonary bypass. [J Thorac Cardiovasc Surg. 2001]
Alternate explanation for the increasing oxygen consumption and lactatemia after surgery with hypothermic cardiopulmonary bypass.
Miyamoto TA, Miyamoto KJ. J Thorac Cardiovasc Surg. 2001 Apr; 121(4):816-7.
Hyperlactatemia during cardiopulmonary bypass: determinants and impact on postoperative outcome. [Crit Care. 2006]
Hyperlactatemia during cardiopulmonary bypass: determinants and impact on postoperative outcome.
Ranucci M, De Toffol B, Isgrò G, Romitti F, Conti D, Vicentini M. Crit Care. 2006; 10(6):R167.
Oxygen consumption, carbon dioxide production and lactic acid during normothermic cardiopulmonary bypass. [Perfusion. 2000]
Oxygen consumption, carbon dioxide production and lactic acid during normothermic cardiopulmonary bypass.
Engoren M, Evans M. Perfusion. 2000 Sep; 15(5):441-6.
Review Perioperative renal failure: hypoperfusion during cardiopulmonary bypass? [Semin Cardiothorac Vasc Anesth. 2007]
Review Perioperative renal failure: hypoperfusion during cardiopulmonary bypass?
Ranucci M. Semin Cardiothorac Vasc Anesth. 2007 Dec; 11(4):265-8.
Review Risk factors for lactic acidosis and severe hyperlactataemia in HIV-1-infected adults exposed to antiretroviral therapy. [AIDS. 2007]
Review Risk factors for lactic acidosis and severe hyperlactataemia in HIV-1-infected adults exposed to antiretroviral therapy.
Lactic Acidosis International Study Group. AIDS. 2007 Nov 30; 21(18):2455-64.

See reviews... See all...

Chemical compound information

Lactic Acid

MW: 90.07 g/mol

MF: C₃H₆O₃

See 19 citations for this compound....

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC

Recent activity

Clear Turn Off Turn On

The origin and interpretation of hyperlactataemia during low oxygen delivery sta...
The origin and interpretation of hyperlactataemia during low oxygen delivery states.
Crit Care. 2007 ;11(1):104.

PubMed
The utility of MRI in predicting radiographic erosions in the metatarsophalangea...
The utility of MRI in predicting radiographic erosions in the metatarsophalangeal joints of the rheumatoid foot: a prospective longitudinal cohort study.
Arthritis Res Ther. 2009 ;11(3):R94. Epub 2009 Jun 22 .

PubMed
Metabolic fluxes in the central carbon metabolism of Dinoroseobacter shibae and ...
Metabolic fluxes in the central carbon metabolism of Dinoroseobacter shibae and Phaeobacter gallaeciensis, two members of the marine Roseobacter clade.
BMC Microbiol. 2009 Sep 29 ;9:209.

PubMed
Descriptive review of geographic mapping of severe acute respiratory syndrome (S...
Descriptive review of geographic mapping of severe acute respiratory syndrome (SARS) on the Internet.
Int J Health Geogr. 2004 Jan 28;3(1):2.

PubMed
Pattern and determinants of HIV research productivity in sub-Saharan Africa: bib...
Pattern and determinants of HIV research productivity in sub-Saharan Africa: bibliometric analysis of 1981 to 2009 PubMed papers.
BMC Infect Dis. 2010 Mar 5 ;10:47.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: