Nat Rev Immunol. 2007 Jan;7(1):64-75. Epub 2006 Dec 15.

Notch signalling during peripheral T-cell activation and differentiation.

Source

Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA. Osborne@vasci.umass.edu

Abstract

For many years, researchers have focused on the contribution of Notch signalling to lymphoid development. Only recently have investigators begun to ask what role, if any, Notch has during the activation and differentiation of naive CD4(+) T cells in the periphery. As interest in this issue grows, it is becoming increasingly clear that the main role of Notch signalling, to regulate cell-fate decisions, might also be influential in peripheral T cells.

PMID:: 17170755; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Receptors, Notch

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Review Notch signaling in the immune system. [Immunity. 2010]
Review Notch signaling in the immune system.
Radtke F, Fasnacht N, Macdonald HR. Immunity. 2010 Jan 29; 32(1):14-27.
Review Notch signaling in lymphocyte development and function. [Curr Opin Immunol. 2004]
Review Notch signaling in lymphocyte development and function.
Robey EA, Bluestone JA. Curr Opin Immunol. 2004 Jun; 16(3):360-6.
Review Regulation of early T cell development in mouse and human by Notch. [Verh K Acad Geneeskd Belg. 2009]
Review Regulation of early T cell development in mouse and human by Notch.
Taghon T. Verh K Acad Geneeskd Belg. 2009; 71(5):301-14.
Review Notch signalling in the regulation of peripheral T-cell function. [Semin Cell Dev Biol. 2003]
Review Notch signalling in the regulation of peripheral T-cell function.
Mckenzie GJ, Young LL, Briend E, Lamb JR, Dallman MJ, Champion BR. Semin Cell Dev Biol. 2003 Apr; 14(2):127-34.
Review Notch signalling at the crossroads of T cell development and leukemogenesis. [Semin Cell Dev Biol. 2003]
Review Notch signalling at the crossroads of T cell development and leukemogenesis.
Campese AF, Bellavia D, Gulino A, Screpanti I. Semin Cell Dev Biol. 2003 Apr; 14(2):151-7.

See reviews... See all...

Cited by 25 PubMed Central articles

Experimental selection of hypoxia-tolerant Drosophila melanogaster. [Proc Natl Acad Sci U S A. 2011]
Experimental selection of hypoxia-tolerant Drosophila melanogaster.
Zhou D, Udpa N, Gersten M, Visk DW, Bashir A, Xue J, Frazer KA, Posakony JW, Subramaniam S, Bafna V, et al. Proc Natl Acad Sci U S A. 2011 Feb 8; 108(6):2349-54. Epub 2011 Jan 24.
Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. [J Immunol. 2010]
Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.
Foldi J, Chung AY, Xu H, Zhu J, Outtz HH, Kitajewski J, Li Y, Hu X, Ivashkiv LB. J Immunol. 2010 Nov 1; 185(9):5023-31. Epub 2010 Sep 24.
Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease. [Blood. 2011]
Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.
Zhang Y, Sandy AR, Wang J, Radojcic V, Shan GT, Tran IT, Friedman A, Kato K, He S, Cui S, et al. Blood. 2011 Jan 6; 117(1):299-308. Epub 2010 Sep 24.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Notch signalling during peripheral T-cell activation and differentiation.
Notch signalling during peripheral T-cell activation and differentiation.
Nat Rev Immunol. 2007 Jan ;7(1):64-75. Epub 2006 Dec 15 .

PubMed
Proteomic analysis of post-translational modifications.
Proteomic analysis of post-translational modifications.
Nat Biotechnol. 2003 Mar ;21(3):255-61.

PubMed
Genomic analysis of a spontaneous model of breast cancer metastasis to bone reve...
Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix.
Mol Cancer Res. 2005 Jan ;3(1):1-13.

PubMed
Liquid chromatography-tandem mass spectrometry assay for simultaneous measuremen...
Liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of estradiol and estrone in human plasma.
Clin Chem. 2004 Feb ;50(2):373-84. Epub 2003 Dec 4 .

PubMed
Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic inst...
Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer.
Oncogene. 2002 Aug 1 ;21(33):5097-107.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: