Genes Immun. 2007 Mar;8(2):115-23. Epub 2006 Dec 14.

Non-B27 MHC associations of ankylosing spondylitis.

Sims AM, Barnardo M, Herzberg I, Bradbury L, Calin A, Wordsworth BP, Darke C, Brown MA.

Source

Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, UK.

Abstract

Ankylosing spondylitis (AS) has been associated with human leukocyte antigen (HLA)-B27 for over 30 years; however, the mechanism of action has remained elusive. Although many studies have reported associations between AS and other genes in the major histocompatibility complex (MHC) in AS, no conclusive results have emerged. To investigate the contribution of non-B27 MHC genes to AS, a large cohort of AS families and controls were B27 typed and genotyped across the region. Interrogation of the data identified a region of 270 kb, lying from 31 952 649 to 32 221 738 base pairs from the p-telomere of chromosome 6 and containing 23 genes, which is likely to include genes involved with susceptibility to AS.

PMID:: 17167495; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

DNA Primers

LinkOut - more resources

Full Text Sources

Medical

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci. [Am J Hum Genet. 2001]
Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci.
Laval SH, Timms A, Edwards S, Bradbury L, Brophy S, Milicic A, Rubin L, Siminovitch KA, Weeks DE, Calin A, et al. Am J Hum Genet. 2001 Apr; 68(4):918-26. Epub 2001 Feb 27.
Review The genetic basis of ankylosing spondylitis. [Curr Opin Rheumatol. 2006]
Review The genetic basis of ankylosing spondylitis.
Reveille JD. Curr Opin Rheumatol. 2006 Jul; 18(4):332-41.
Investigating the genetic basis for ankylosing spondylitis. Linkage studies with the major histocompatibility complex region. [Arthritis Rheum. 1994]
Investigating the genetic basis for ankylosing spondylitis. Linkage studies with the major histocompatibility complex region.
Rubin LA, Amos CI, Wade JA, Martin JR, Bale SJ, Little AH, Gladman DD, Bonney GE, Rubenstein JD, Siminovitch KA. Arthritis Rheum. 1994 Aug; 37(8):1212-20.
Distribution of HLA-B*27 subtypes in Tunisians and their association with ankylosing spondylitis. [Joint Bone Spine. 2008]
Distribution of HLA-B*27 subtypes in Tunisians and their association with ankylosing spondylitis.
Ben Radhia K, Ayed-Jendoubi S, Sfar I, Ben Romdhane T, Makhlouf M, Gorgi Y, Ayed K. Joint Bone Spine. 2008 Mar; 75(2):172-5. Epub 2008 Jan 29.
Review Major histocompatibility genes and ankylosing spondylitis. [Best Pract Res Clin Rheumatol....]
Review Major histocompatibility genes and ankylosing spondylitis.
Reveille JD. Best Pract Res Clin Rheumatol. 2006 Jun; 20(3):601-9.

See reviews... See all...

Cited by 4 PubMed Central articles

HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia. [Arthritis Res Ther. 2009]
HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia.
Paladini F, Belfiore F, Cocco E, Carcassi C, Cauli A, Vacca A, Fiorillo MT, Mathieu A, Cascino I, Sorrentino R. Arthritis Res Ther. 2009; 11(6):R171. Epub 2009 Nov 13.
Review Progress in spondylarthritis. Progress in studies of the genetics of ankylosing spondylitis. [Arthritis Res Ther. 2009]
Review Progress in spondylarthritis. Progress in studies of the genetics of ankylosing spondylitis.
Brown MA. Arthritis Res Ther. 2009; 11(5):254. Epub 2009 Oct 29.
Association of chromosome 2q36.1-36.3 and autosomal dominant transmission in ankylosing spondylitis: results of genetic studies across generations of Han Chinese families. [J Med Genet. 2009]
Association of chromosome 2q36.1-36.3 and autosomal dominant transmission in ankylosing spondylitis: results of genetic studies across generations of Han Chinese families.
Gu J, Huang J, Li C, Zhao L, Huang F, Liao Z, Li T, Wei Q, Lin Z, Pan Y, et al. J Med Genet. 2009 Oct; 46(10):657-62. Epub 2009 May 4.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Non-B27 MHC associations of ankylosing spondylitis.
Non-B27 MHC associations of ankylosing spondylitis.
Genes Immun. 2007 Mar ;8(2):115-23. Epub 2006 Dec 14 .

PubMed
Induction of experimental Candida arthritis in rats.
Induction of experimental Candida arthritis in rats.
J Med Vet Mycol. 1991 ;29(3):179-92.

PubMed
Identification of patients with early rheumatoid arthritis: challenges and futur...
Identification of patients with early rheumatoid arthritis: challenges and future directions.
Clin Dev Immunol. 2006 Jun-Dec ;13(2-4):295-7.

PubMed
Murine osteogenic protein (OP-1): high levels of mRNA in kidney.
Murine osteogenic protein (OP-1): high levels of mRNA in kidney.
Biochem Biophys Res Commun. 1991 Aug 30 ;179(1):116-23.

PubMed
The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthriti...
The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein.
Arthritis Res Ther. 2006 ;8(6):R181.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: