J Biol Chem. 1991 Jul 25;266(21):14055-63.

Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events.

Quiñones MA, Mundschau LJ, Rake JB, Faller DV.

Source

Brigham and Women's Hospital, Boston, Massachusetts.

Abstract

Activated p21ras alters the platelet-derived growth factor (PDGF) signal transduction pathway in fibroblasts by inhibiting autophosphorylation of the receptor as well as by inhibiting the induction of the growth-related genes c-myc, c-fos, and JE. To elucidate the cause and effect relationships between receptor autophosphorylation and other second messenger events in the PDGF signaling pathway we created revertants of v-ras transformed cells by two methods: 1) the use of cAMP analogues, and 2) the introduction of a gene, Krev-1, which has been reported previously to revert ras transformed cells to normal morphology. Analysis of the revertants shows that the PDGF-mediated tyrosine phosphorylation of the 180-kDa PDGF receptor remains inhibited; however, the PDGF-mediated activation of phospholipase C and the induction of the growth-related genes c-myc, c-fos, and JE have been restored. These data suggest the presence of parallel pathways for PDGF signal transduction which are not dependent on autophosphorylation of the PDGF receptor.

PMID:: 1713214; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

HighWire Press - PDF

Other Literature Sources

COS Scholar Universe

Molecular Biology Databases

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Platelet-derived growth factor (PDGF) induction of egr-1 is independent of PDGF receptor autophosphorylation on tyrosine. [J Biol Chem. 1994]
Platelet-derived growth factor (PDGF) induction of egr-1 is independent of PDGF receptor autophosphorylation on tyrosine.
Mundschau LJ, Forman LW, Weng H, Faller DV. J Biol Chem. 1994 Jun 10; 269(23):16137-42.
Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types. [Mol Cell Biol. 1993]
Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types.
Satoh T, Fantl WJ, Escobedo JA, Williams LT, Kaziro Y. Mol Cell Biol. 1993 Jun; 13(6):3706-13.
Compartmentalization of autocrine signal transduction pathways in Sis-transformed NIH 3T3 cells. [J Biol Chem. 1995]
Compartmentalization of autocrine signal transduction pathways in Sis-transformed NIH 3T3 cells.
Valgeirsdóttir S, Eriksson A, Nistér M, Heldin CH, Westermark B, Claesson-Welsh L. J Biol Chem. 1995 Apr 28; 270(17):10161-70.
Review Regulation of platelet-derived growth factor signaling by activated p21Ras. [Front Biosci. 1999]
Review Regulation of platelet-derived growth factor signaling by activated p21Ras.
Stice LL, Vaziri C, Faller DV. Front Biosci. 1999 Jan 15; 4:D72-86. Epub 1999 Jan 15.
Review Platelet derived growth factor/tyrosine kinase receptor mediated proliferation. [Growth Regul. 1993]
Review Platelet derived growth factor/tyrosine kinase receptor mediated proliferation.
Benito M, Lorenzo M. Growth Regul. 1993 Sep; 3(3):172-9.

See reviews... See all...

Cited by 3 PubMed Central articles

Transactivation of PDGFRbeta by dopamine D4 receptor does not require PDGFRbeta dimerization. [Mol Brain. 2010]
Transactivation of PDGFRbeta by dopamine D4 receptor does not require PDGFRbeta dimerization.
Chi SS, Vetiska SM, Gill RS, Hsiung MS, Liu F, Van Tol HH. Mol Brain. 2010 Jul 26; 3:22. Epub 2010 Jul 26.
Involvement of a phosphotyrosine protein phosphatase in the suppression of platelet-derived growth factor receptor autophosphorylation in ras-transformed cells. [Biochem J. 1993]
Involvement of a phosphotyrosine protein phosphatase in the suppression of platelet-derived growth factor receptor autophosphorylation in ras-transformed cells.
Tomáska L, Resnick RJ. Biochem J. 1993 Jul 1; 293 ( Pt 1):215-21.
Repression of platelet-derived growth factor beta-receptor expression by mitogenic growth factors and transforming oncogenes in murine 3T3 fibroblasts. [Mol Cell Biol. 1995]
Repression of platelet-derived growth factor beta-receptor expression by mitogenic growth factors and transforming oncogenes in murine 3T3 fibroblasts.
Vaziri C, Faller DV. Mol Cell Biol. 1995 Mar; 15(3):1244-53.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylati...
Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events.
J Biol Chem. 1991 Jul 25 ;266(21):14055-63.

PubMed
RNA interference-mediated knockdown of alpha-synuclein protects human dopaminerg...
RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport.
J Neurosci Res. 2007 Feb 1 ;85(2):351-63.

PubMed
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide ...
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry.
J Immunol Methods. 1991 Jun 3 ;139(2):271-9.

PubMed
Ablation of hippocampal neurogenesis impairs contextual fear conditioning and sy...
Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus.
Proc Natl Acad Sci U S A. 2006 Nov 14 ;103(46):17501-6. Epub 2006 Nov 6 .

PubMed
Noradrenergic and locus coeruleus modulation of the perforant path-evoked potent...
Noradrenergic and locus coeruleus modulation of the perforant path-evoked potential in rat dentate gyrus supports a role for the locus coeruleus in attentional and memorial processes.
Prog Brain Res. 1991 ;88:307-21.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: