Endocrinol Metab Clin North Am. 2006 Dec;35(4):859-72, x.

Diabetes of injury: novel insights.

Source

Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-300 Leuven, Belgium.

Abstract

Critically ill patients usually develop hyperglycemia, a condition referred to as "diabetes of injury." More and more evidence argues against the concept that this is an adaptive beneficial response. Indeed, the development of hyperglycemia seems to be detrimental for the outcome of critically ill patients, because maintenance of normoglycemia with intensive insulin therapy prevents morbidity and reduces mortality of critically ill patients to a large extent. The mechanisms underlying these clinical benefits are being studied further.

PMID:: 17127151; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Insulin

LinkOut - more resources

Full Text Sources

Medical

Diabetes Medicines - MedlinePlus Health Information

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Review Clinical potential of insulin therapy in critically ill patients. [Drugs. 2003]
Review Clinical potential of insulin therapy in critically ill patients.
Mesotten D, Van den Berghe G. Drugs. 2003; 63(7):625-36.
Review [Hyperglycemia in the critically ill: meaning and treatment]. [Presse Med. 2009]
Review [Hyperglycemia in the critically ill: meaning and treatment].
Schlienger JL, Pradignac A, Vinzio S, Luca F, Suna C, Grunenberger F, Goichot B. Presse Med. 2009 Apr; 38(4):562-70. Epub 2008 Dec 3.
Review Hyperglycemia in the intensive care unit: no longer just a marker of illness severity. [Surg Infect (Larchmt). 2005]
Review Hyperglycemia in the intensive care unit: no longer just a marker of illness severity.
Taylor JH, Beilman GJ. Surg Infect (Larchmt). 2005; 6(2):233-45.
Review [Insulin infusion for critically ill patients]. [Tidsskr Nor Laegeforen. 2007]
Review [Insulin infusion for critically ill patients].
Skeie S, Søreide E, Cooper J. Tidsskr Nor Laegeforen. 2007 Sep 20; 127(18):2378-81.
Review Glycemic and nonglycemic effects of insulin: how do they contribute to a better outcome of critical illness? [Curr Opin Crit Care. 2005]
Review Glycemic and nonglycemic effects of insulin: how do they contribute to a better outcome of critical illness?
Vanhorebeek I, Langouche L, Van den Berghe G. Curr Opin Crit Care. 2005 Aug; 11(4):304-11.

See reviews... See all...

Cited by 3 PubMed Central articles

Review Glycemic control in the medical intensive care unit. [J Diabetes Sci Technol. 2009]
Review Glycemic control in the medical intensive care unit.
Kovalaske MA, Gandhi GY. J Diabetes Sci Technol. 2009 Nov 1; 3(6):1330-41. Epub 2009 Nov 1.
Review Stress hyperglycaemia. [Lancet. 2009]
Review Stress hyperglycaemia.
Dungan KM, Braithwaite SS, Preiser JC. Lancet. 2009 May 23; 373(9677):1798-807.
Glycemic penalty index for adequately assessing and comparing different blood glucose control algorithms. [Crit Care. 2008]
Glycemic penalty index for adequately assessing and comparing different blood glucose control algorithms.
Van Herpe T, De Brabanter J, Beullens M, De Moor B, Van den Berghe G. Crit Care. 2008; 12(1):R24. Epub 2008 Feb 26.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Diabetes of injury: novel insights.
Diabetes of injury: novel insights.
Endocrinol Metab Clin North Am. 2006 Dec ;35(4):859-72, x.

PubMed
Prehospital hypertonic saline/dextran infusion for post-traumatic hypotension. T...
Prehospital hypertonic saline/dextran infusion for post-traumatic hypotension. The U.S.A. Multicenter Trial.
Ann Surg. 1991 May ;213(5):482-91.

PubMed
Variability of voriconazole plasma levels measured by new high-performance liqui...
Variability of voriconazole plasma levels measured by new high-performance liquid chromatography and bioassay methods.
Antimicrob Agents Chemother. 2007 Jan ;51(1):137-43. Epub 2006 Nov 6 .

PubMed
Glutamate, nitric oxide and cell-cell signalling in the nervous system.
Glutamate, nitric oxide and cell-cell signalling in the nervous system.
Trends Neurosci. 1991 Feb ;14(2):60-7.

PubMed
Pulmonary artery catheter and fluid management in acute lung injury and the acut...
Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome.
Clin Chest Med. 2006 Dec ;27(4):627-35; abstract ix.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: