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    C R Biol. 2006 Dec;329(12):919-27. Epub 2006 Sep 7.

    [The PAI-1 swing: microenvironment and cancer cell migration].

    [Article in French]
    Malo M, Charrière-Bertrand C, Chettaoui C, Fabre-Guillevin E, Maquerlot F, Lackmy A, Vallée B, Delaplace F, Barlovatz-Meimon G.

    Source

    Equipe DYNAMIC, Dynamique du Microenvironnement Cellulaire, Informatique, Biologie Intégrative et Systèmes Complexes), FRE 2873 CNRS, Université d'Evry-Val d'Essonne, Université Paris 12, Génopole, France.

    Abstract

    Cancer is a complex and dynamic process caused by a cellular dysfunction leading to a whole organ or even organism vital perturbation. To better understand this process, we need to study each one of the levels involved, which allows the scale change, and to integrate this knowledge. A matricellular protein, PAI-1, is able to induce in vitro cell behaviour modifications, morphological changes, and to promote cell migration. PAI-1 influences the mesenchymo-amaeboid transition. This matricellular protein should be considered as a potential 'launcher' of the metastatic process acting at the molecular, cellular, tissular levels and, as a consequence, at the organism's level.

    PMID:
    17126795
    [PubMed - indexed for MEDLINE]

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      Cited by 1 PubMed Central article

      • PAI-1 and functional blockade of SNAI1 in breast cancer cell migration. [Breast Cancer Res. 2008]
        PAI-1 and functional blockade of SNAI1 in breast cancer cell migration.
        Fabre-Guillevin E, Malo M, Cartier-Michaud A, Peinado H, Moreno-Bueno G, Vallée B, Lawrence DA, Palacios J, Cano A, Barlovatz-Meimon G, et al. Breast Cancer Res. 2008; 10(6):R100. Epub 2008 Dec 3.

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