Physiology (Bethesda). 2006 Dec;21:430-9.

Lipid rafts, detergent-resistant membranes, and raft targeting signals.

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Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, USA. deborah.brown@sunysb.edu

Abstract

Lipid rafts are liquid-ordered (l(o)) phase microdomains proposed to exist in biological membranes. Rafts have been widely studied by isolating l(o)-phase detergent-resistant membranes (DRMs) from cells. Recent findings have shown that DRMs are not the same as preexisting rafts, prompting a major revision of the raft model. Nevertheless, raft-targeting signals identified by DRM analysis are often required for protein function, implicating rafts in a variety of cell processes.

PMID:: 17119156; [PubMed - indexed for MEDLINE]

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