Nucleic Acids Res. 1991 May 25;19(10):2707-14.

A comparison of optimal and suboptimal RNA secondary structures predicted by free energy minimization with structures determined by phylogenetic comparison.

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Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario.

Abstract

This article describes the latest version of an RNA folding algorithm that predicts both optimal and suboptimal solutions based on free energy minimization. A number of RNA's with known structures deduced from comparative sequence analysis are folded to test program performance. The group of solutions obtained for each molecule is analysed to determine how many of the known helixes occur in the optimal solution and in the best suboptimal solution. In most cases, a structure about 80% correct is found with a free energy within 2% of the predicted lowest free energy structure.

PMID:: 1710343; [PubMed - indexed for MEDLINE]
PMCID:: PMC328190

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