Cell. 1991 May 31;65(5):837-47.

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.

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Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461.

Abstract

unc-104 encodes a novel kinesin paralog that may act as a microtubule-based motor in the nervous system. Neuronal cell lineages and axonogenesis are normal in unc-104 null mutants, but axons have few synaptic vesicles and make only a few small synapses. By contrast, neuron cell bodies have surfeits of similar vesicles tethered together within the cytoplasm. Based on behavioral and cellular phenotypes, we suggest that UNC-104 is a neuron-specific motor used for anterograde translocation of synaptic vesicles along axonal microtubules. Other membrane-bounded organelles are transported normally.

PMID:: 1710172; [PubMed - indexed for MEDLINE]

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