Nat Rev Cancer. 2006 Nov;6(11):857-66.

MicroRNA signatures in human cancers.

Source

Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

Abstract

MicroRNA (miRNA) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer.

PMID:: 17060945; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Investigation of microRNA alterations in leukemias and lymphomas. [Methods Enzymol. 2007]
Investigation of microRNA alterations in leukemias and lymphomas.
Calin GA, Croce CM. Methods Enzymol. 2007; 427:193-213.
Review Non-coding RNAs for medical practice in oncology. [Keio J Med. 2011]
Review Non-coding RNAs for medical practice in oncology.
Setoyama T, Ling H, Natsugoe S, Calin GA. Keio J Med. 2011; 60(4):106-13.
Review MicroRNA expression profiling in cancer from a bioinformatics prospective. [Expert Rev Mol Diagn. 2007]
Review MicroRNA expression profiling in cancer from a bioinformatics prospective.
Gusev Y, Brackett DJ. Expert Rev Mol Diagn. 2007 Nov; 7(6):787-92.
Global gene expression analysis reveals reduced abundance of putative microRNA targets in human prostate tumours. [BMC Genomics. 2009]
Global gene expression analysis reveals reduced abundance of putative microRNA targets in human prostate tumours.
Sun R, Fu X, Li Y, Xie Y, Mao Y. BMC Genomics. 2009 Feb 26; 10:93. Epub 2009 Feb 26.
Review Mechanisms of microRNA deregulation in human cancer. [Cell Cycle. 2008]
Review Mechanisms of microRNA deregulation in human cancer.
Deng S, Calin GA, Croce CM, Coukos G, Zhang L. Cell Cycle. 2008 Sep 1; 7(17):2643-6. Epub 2008 Sep 12.

See reviews... See all...

Cited by over 100 PubMed Central articles

A Panel of Serum MicroRNAs as Specific Biomarkers for Diagnosis of Compound- and Herb-Induced Liver Injury in Rats. [PLoS One. 2012]
A Panel of Serum MicroRNAs as Specific Biomarkers for Diagnosis of Compound- and Herb-Induced Liver Injury in Rats.
Su YW, Chen X, Jiang ZZ, Wang T, Wang C, Zhang Y, Wen J, Xue M, Zhu D, Zhang Y, et al. PLoS One. 2012; 7(5):e37395. Epub 2012 May 18.
Identification of a 4-microRNA Signature for Clear Cell Renal Cell Carcinoma Metastasis and Prognosis. [PLoS One. 2012]
Identification of a 4-microRNA Signature for Clear Cell Renal Cell Carcinoma Metastasis and Prognosis.
Wu X, Weng L, Li X, Guo C, Pal SK, Jin JM, Li Y, Nelson RA, Mu B, Onami SH, et al. PLoS One. 2012; 7(5):e35661. Epub 2012 May 18.
Integrated Analysis Reveals hsa-miR-142 as a Representative of a Lymphocyte-Specific Gene Expression and Methylation Signature. [Cancer Inform. 2012]
Integrated Analysis Reveals hsa-miR-142 as a Representative of a Lymphocyte-Specific Gene Expression and Methylation Signature.
Andreopoulos B, Anastassiou D. Cancer Inform. 2012; 11:61-75. Epub 2012 Mar 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

MicroRNA signatures in human cancers.
MicroRNA signatures in human cancers.
Nat Rev Cancer. 2006 Nov ;6(11):857-66.

PubMed
Equine infectious anemia virus and human immunodeficiency virus DNA synthesis in...
Equine infectious anemia virus and human immunodeficiency virus DNA synthesis in vitro: characterization of the endogenous reverse transcriptase reaction.
J Virol. 1991 Apr ;65(4):1952-9.

PubMed
Humanized mice mount specific adaptive and innate immune responses to EBV and TS...
Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.
Nat Med. 2006 Nov ;12(11):1316-22. Epub 2006 Oct 22 .

PubMed
The preparation of highly enriched fractions of binucleated rat hepatocytes by c...
The preparation of highly enriched fractions of binucleated rat hepatocytes by centrifugal elutriation and flow cytometry.
Anal Biochem. 1990 Nov 1 ;190(2):266-70.

PubMed
Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2...
Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004.
AIDS. 2006 Oct 24 ;20(16):W13-23.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

MicroRNA signatures in human cancers.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information