Science. 1991 Feb 8;251(4994):668-71.

Inability of malaria vaccine to induce antibodies to a protective epitope within its sequence.

Charoenvit Y, Collins WE, Jones TR, Millet P, Yuan L, Campbell GH, Beaudoin RL, Broderson JR, Hoffman SL.

Source

Infectious Diseases Department, Naval Medical Research Institute, Bethesda, MD 20889.

Abstract

Saimiri monkeys immunized with a recombinant protein containing 20 copies of the nine amino acid repeat of the Plasmodium vivax circumsporozoite (CS) protein developed high concentrations of antibodies to the repeat sequence and to sporozoites, but were not protected against challenge. After intravenous injection of an immunoglobulin G3 monoclonal antibody (NVS3) against irradiated P. vivax sporozoites, four of six monkeys were protected against sporozoite-induced malaria, and the remaining two animals took significantly longer to become parasitemic. Epitope mapping demonstrated that NVS3 recognizes only four (AGDR) of the nine amino acids within the repeat region of the P. vivax CS protein. The monkeys immunized with (DRAADGQPAG)20 did not produce antibodies to the protective epitope AGDR. Thus, determination of the fine specificity of protective immune responses may be critical to the construction of successful subunit vaccines.

PMID:: 1704150; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Induction of protective antibodies in Saimiri monkeys by immunization with a multiple antigen construct (MAC) containing the Plasmodium vivax circumsporozoite protein repeat region and a universal T helper epitope of tetanus toxin. [Vaccine. 1997]
Induction of protective antibodies in Saimiri monkeys by immunization with a multiple antigen construct (MAC) containing the Plasmodium vivax circumsporozoite protein repeat region and a universal T helper epitope of tetanus toxin.
Yang C, Collins WE, Xiao L, Saekhou AM, Reed RC, Nelson CO, Hunter RL, Jue DL, Fang S, Wohlhueter RM, et al. Vaccine. 1997 Mar; 15(4):377-86.
Low immunogenicity of a Plasmodium vivax circumsporozoite protein epitope bound by a protective monoclonal antibody. [Am J Trop Med Hyg. 1992]
Low immunogenicity of a Plasmodium vivax circumsporozoite protein epitope bound by a protective monoclonal antibody.
Jones TR, Yuan LF, Marwoto HA, Gordon DM, Wirtz RA, Hoffman SL. Am J Trop Med Hyg. 1992 Dec; 47(6):837-43.
Inhibitory activity against sporozoites induced by antibodies directed against nonrepetitive regions of the circumsporozoite protein of Plasmodium vivax. [Eur J Immunol. 1992]
Inhibitory activity against sporozoites induced by antibodies directed against nonrepetitive regions of the circumsporozoite protein of Plasmodium vivax.
Millet P, Chizzolini C, Wirtz RA, Bathurst I, Broderson JR, Campbell GH, Collins WE. Eur J Immunol. 1992 Feb; 22(2):519-24.
Review Antibodies to the circumsporozoite protein and protective immunity to malaria sporozoites. [Prog Clin Parasitol. 1993]
Review Antibodies to the circumsporozoite protein and protective immunity to malaria sporozoites.
Jones TR, Ballou WR, Hoffman SL. Prog Clin Parasitol. 1993; 3:103-17.
Review Dissection of the human antibody response to the malaria antigen Pf155/RESA into epitope specific components. [Immunol Rev. 1989]
Review Dissection of the human antibody response to the malaria antigen Pf155/RESA into epitope specific components.
Perlmann H, Perlmann P, Berzins K, Wåhlin B, Troye-Blomberg M, Hagstedt M, Andersson I, Högh B, Petersen E, Björkman A. Immunol Rev. 1989 Dec; 112:115-32.

See reviews... See all...

Cited by 19 PubMed Central articles

Antigen-displaying lipid-enveloped PLGA nanoparticles as delivery agents for a Plasmodium vivax malaria vaccine. [PLoS One. 2012]
Antigen-displaying lipid-enveloped PLGA nanoparticles as delivery agents for a Plasmodium vivax malaria vaccine.
Moon JJ, Suh H, Polhemus ME, Ockenhouse CF, Yadava A, Irvine DJ. PLoS One. 2012; 7(2):e31472. Epub 2012 Feb 6.
Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction. [Proc Natl Acad Sci U S A. 2012]
Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction.
Moon JJ, Suh H, Li AV, Ockenhouse CF, Yadava A, Irvine DJ. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1080-5. Epub 2012 Jan 12.
Evaluation of the safety and immunogenicity in rhesus monkeys of a recombinant malaria vaccine for Plasmodium vivax with a synthetic Toll-like receptor 4 agonist formulated in an emulsion. [Infect Immun. 2011]
Evaluation of the safety and immunogenicity in rhesus monkeys of a recombinant malaria vaccine for Plasmodium vivax with a synthetic Toll-like receptor 4 agonist formulated in an emulsion.
Lumsden JM, Pichyangkul S, Srichairatanakul U, Yongvanitchit K, Limsalakpetch A, Nurmukhambetova S, Klein J, Bertholet S, Vedvick TS, Reed SG, et al. Infect Immun. 2011 Sep; 79(9):3492-500. Epub 2011 Jun 20.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Inability of malaria vaccine to induce antibodies to a protective epitope within...
Inability of malaria vaccine to induce antibodies to a protective epitope within its sequence.
Science. 1991 Feb 8 ;251(4994):668-71.

PubMed
Critical comparison of 31 commercially available digital slide systems in pathol...
Critical comparison of 31 commercially available digital slide systems in pathology.
Int J Surg Pathol. 2006 Oct ;14(4):285-305.

PubMed
Further studies on the immunization of Saimiri sciureus boliviensis with recombi...
Further studies on the immunization of Saimiri sciureus boliviensis with recombinant vaccines based on the circumsporozoite protein of Plasmodium vivax.
Am J Trop Med Hyg. 1990 Dec ;43(6):576-83.

PubMed
Genotypes and in vivo resistance of Plasmodium falciparum isolates in an endemic...
Genotypes and in vivo resistance of Plasmodium falciparum isolates in an endemic region of Iran.
Parasitol Res. 2007 Feb ;100(3):589-92. Epub 2006 Sep 26 .

PubMed
A semi-empirical method for prediction of antigenic determinants on protein anti...
A semi-empirical method for prediction of antigenic determinants on protein antigens.
FEBS Lett. 1990 Dec 10 ;276(1-2):172-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Inability of malaria vaccine to induce antibodies to a protective epitope within its sequence.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 19 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information