Int J Surg Pathol. 2006 Oct;14(4):285-305.

Critical comparison of 31 commercially available digital slide systems in pathology.

Rojo MG, García GB, Mateos CP, García JG, Vicente MC.

Source

Pathology Department, Hospital General de Ciudad Real, Spain. marcial@cim.es

Abstract

Advances in new technologies for complete slide digitization in pathology have allowed the appearance of a wide spectrum of technologic solutions for whole-slide scanning, which have been classified into motorized microscopes and scanners. This article describes technical aspects of 31 different digital microscopy systems. The most relevant characteristics of the scanning devices are described, including the cameras used, the speed of digitization, and the image quality. Other aspects, such as the file format, the compression techniques, and the solutions for visualization of digital slides, (including diagnosis-aided tools) are also considered. Most of the systems evaluated allow a high-resolution digitization of the whole slide within about 1 hour using a x40 objective. The image quality of the current virtual microscopy systems is suitable for clinical, educational, and research purposes. The efficient use of digital microscopy by means of image analysis systems can offer important benefits to pathology departments.

PMID:: 17041192; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

An array microscope for ultrarapid virtual slide processing and telepathology. Design, fabrication, and validation study. [Hum Pathol. 2004]
An array microscope for ultrarapid virtual slide processing and telepathology. Design, fabrication, and validation study.
Weinstein RS, Descour MR, Liang C, Barker G, Scott KM, Richter L, Krupinski EA, Bhattacharyya AK, Davis JR, Graham AR, et al. Hum Pathol. 2004 Nov; 35(11):1303-14.
Review Utility of whole slide imaging and virtual microscopy in prostate pathology. [APMIS. 2012]
Review Utility of whole slide imaging and virtual microscopy in prostate pathology.
Camparo P, Egevad L, Algaba F, Berney DM, Boccon-Gibod L, Compérat E, Evans AJ, Grobholz R, Kristiansen G, Langner C, et al. APMIS. 2012 Apr; 120(4):298-304.
Virtual microscopy: high resolution digital photomicrography as a tool for light microscopy simulation. [Hum Pathol. 1999]
Virtual microscopy: high resolution digital photomicrography as a tool for light microscopy simulation.
Felten CL, Strauss JS, Okada DH, Marchevsky AM. Hum Pathol. 1999 Apr; 30(4):477-83.
The virtual case: a new method to completely digitize cytological and histological slides. [Virchows Arch. 2002]
The virtual case: a new method to completely digitize cytological and histological slides.
Demichelis F, Barbareschi M, Dalla Palma P, Forti S. Virchows Arch. 2002 Aug; 441(2):159-64. Epub 2001 Dec 12.
Review [Virtual microscopy systems: analysis and perspectives]. [Biomedica. 2011]
Review [Virtual microscopy systems: analysis and perspectives].
Marín D, Romero E. Biomedica. 2011 Mar; 31(1):144-55.

See reviews... See all...

Cited by 18 PubMed Central articles

SurfaceSlide: a multitouch digital pathology platform. [PLoS One. 2012]
SurfaceSlide: a multitouch digital pathology platform.
Wang Y, Williamson KE, Kelly PJ, James JA, Hamilton PW. PLoS One. 2012; 7(1):e30783. Epub 2012 Jan 23.
Telecytology: Clinical applications, current challenges, and future benefits. [J Pathol Inform. 2011]
Telecytology: Clinical applications, current challenges, and future benefits.
Thrall M, Pantanowitz L, Khalbuss W. J Pathol Inform. 2011; 2:51. Epub 2011 Dec 26.
Autofocus methods of whole slide imaging systems and the introduction of a second-generation independent dual sensor scanning method. [J Pathol Inform. 2011]
Autofocus methods of whole slide imaging systems and the introduction of a second-generation independent dual sensor scanning method.
Montalto MC, McKay RR, Filkins RJ. J Pathol Inform. 2011; 2:44. Epub 2011 Oct 19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Critical comparison of 31 commercially available digital slide systems in pathol...
Critical comparison of 31 commercially available digital slide systems in pathology.
Int J Surg Pathol. 2006 Oct ;14(4):285-305.

PubMed
Further studies on the immunization of Saimiri sciureus boliviensis with recombi...
Further studies on the immunization of Saimiri sciureus boliviensis with recombinant vaccines based on the circumsporozoite protein of Plasmodium vivax.
Am J Trop Med Hyg. 1990 Dec ;43(6):576-83.

PubMed
Genotypes and in vivo resistance of Plasmodium falciparum isolates in an endemic...
Genotypes and in vivo resistance of Plasmodium falciparum isolates in an endemic region of Iran.
Parasitol Res. 2007 Feb ;100(3):589-92. Epub 2006 Sep 26 .

PubMed
A semi-empirical method for prediction of antigenic determinants on protein anti...
A semi-empirical method for prediction of antigenic determinants on protein antigens.
FEBS Lett. 1990 Dec 10 ;276(1-2):172-4.

PubMed
Plasmodium falciparum anti-MSP1-19 antibodies induced by MSP1-42 and MSP1-19 bas...
Plasmodium falciparum anti-MSP1-19 antibodies induced by MSP1-42 and MSP1-19 based vaccines differed in specificity and parasite growth inhibition in terms of recognition of conserved versus variant epitopes.
Vaccine. 2007 Jan 15 ;25(5):948-56. Epub 2006 Sep 18 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: