Warning: The NCBI web site requires JavaScript to function. more...

My NCBI Sign In

Result Filters

J Virol. 2006 Dec;80(24):11998-2008. Epub 2006 Oct 11.

Spleen-dependent turnover of CD11b peripheral blood B lymphocytes in bovine leukemia virus-infected sheep.

Florins A, Gillet N, Asquith B, Debacq C, Jean G, Schwartz-Cornil I, Bonneau M, Burny A, Reichert M, Kettmann R, Willems L.

Source

National Fund for Scientific Research, Molecular and Cellular Biology Laboratory, 13 avenue Maréchal Juin, 5030 Gembloux, Belgium.

Abstract

Lymphocyte homeostasis is determined by a critical balance between cell proliferation and death, an equilibrium which is deregulated in bovine leukemia virus (BLV)-infected sheep. We have previously shown that an excess of proliferation occurs in lymphoid tissues and that the peripheral blood population is prone to increased cell death. To further understand the mechanisms involved, we evaluated the physiological role of the spleen in this accelerated turnover. To this end, B lymphocytes were labeled in vivo using a fluorescent marker (carboxyfluorescein diacetate succinimidyl ester), and the cell kinetic parameters (proliferation and death rates) of animals before and after splenectomy were compared. We show that the enhanced cell death observed in BLV-infected sheep is abrogated after splenectomy, revealing a key role of the spleen in B-lymphocyte dynamics.

PMID:: 17035334; [PubMed - indexed for MEDLINE]
PMCID:: PMC1676270

Free PMC Article

Images from this publication.See all images (6) Free text

FIG. 1.

FIG. 3.

FIG. 5.

FIG. 2.

FIG. 4.

FIG. 6.

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Libraries

LinkOut Holdings

Supplemental Content

Icon for HighWire Press

Icon for PubMed Central

Save items

loading

Related citations in PubMed

Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep. [J Virol. 2006]
Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep.
Debacq C, Gillet N, Asquith B, Sanchez-Alcaraz MT, Florins A, Boxus M, Schwartz-Cornil I, Bonneau M, Jean G, Kerkhofs P, et al. J Virol. 2006 Oct; 80(19):9710-9.
Review Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease. [Vet Immunol Immunopathol. 2008]
Review Emphasis on cell turnover in two hosts infected by bovine leukemia virus: a rationale for host susceptibility to disease.
Florins A, Boxus M, Vandermeers F, Verlaeten O, Bouzar AB, Defoiche J, Hubaux R, Burny A, Kettmann R, Willems L. Vet Immunol Immunopathol. 2008 Sep 15; 125(1-2):1-7. Epub 2008 Apr 16.
Increased cell proliferation, but not reduced cell death, induces lymphocytosis in bovine leukemia virus-infected sheep. [Proc Natl Acad Sci U S A. 2002]
Increased cell proliferation, but not reduced cell death, induces lymphocytosis in bovine leukemia virus-infected sheep.
Debacq C, Asquith B, Kerkhofs P, Portetelle D, Burny A, Kettmann R, Willems L. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):10048-53. Epub 2002 Jul 15.
Ex vivo survival of peripheral blood mononuclear cells in sheep induced by bovine leukemia virus (BLV) mainly occurs in CD5- B cells that express BLV. [Microbes Infect. 2004]
Ex vivo survival of peripheral blood mononuclear cells in sheep induced by bovine leukemia virus (BLV) mainly occurs in CD5- B cells that express BLV.
Takahashi M, Tajima S, Takeshima SN, Konnai S, Yin SA, Okada K, Davis WC, Aida Y. Microbes Infect. 2004 May; 6(6):584-95.
Review Cell dynamics and immune response to BLV infection: a unifying model. [Front Biosci. 2007]
Review Cell dynamics and immune response to BLV infection: a unifying model.
Florins A, Gillet N, Asquith B, Boxus M, Burteau C, Twizere JC, Urbain P, Vandermeers F, Debacq C, Sanchez-Alcaraz MT, et al. Front Biosci. 2007 Jan 1; 12:1520-31. Epub 2007 Jan 1.

See reviews... See all...

Cited by 3 PubMed Central articles

Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads. [Retrovirology. 2009]
Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads.
Bouzar AB, Boxus M, Florins A, François C, Reichert M, Willems L. Retrovirology. 2009 Nov 10; 6:102. Epub 2009 Nov 10.
Earlier onset of delta-retrovirus-induced leukemia after splenectomy. [PLoS One. 2009]
Earlier onset of delta-retrovirus-induced leukemia after splenectomy.
Florins A, Reichert M, Asquith B, Bouzar AB, Jean G, François C, Jasik A, Burny A, Kettmann R, Willems L. PLoS One. 2009 Sep 14; 4(9):e6943. Epub 2009 Sep 14.
Review Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human. [Retrovirology. 2007]
Review Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human.
Gillet N, Florins A, Boxus M, Burteau C, Nigro A, Vandermeers F, Balon H, Bouzar AB, Defoiche J, Burny A, et al. Retrovirology. 2007 Mar 16; 4:18. Epub 2007 Mar 16.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Spleen-dependent turnover of CD11b peripheral blood B lymphocytes in bovine leuk...
Spleen-dependent turnover of CD11b peripheral blood B lymphocytes in bovine leukemia virus-infected sheep.
J Virol. 2006 Dec ;80(24):11998-2008. Epub 2006 Oct 11 .

PubMed
Detection of surface and cytoplasmic CD4 on blood monocytes from normal and HIV-...
Detection of surface and cytoplasmic CD4 on blood monocytes from normal and HIV-1 infected individuals.
J Immunol Methods. 1990 Dec 31 ;135(1-2):59-69.

PubMed
High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition.
High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition.
Proc Natl Acad Sci U S A. 2006 Oct 17 ;103(42):15588-93. Epub 2006 Oct 9 .

PubMed
Inactivation of the Moloney murine leukemia virus long terminal repeat in murine...
Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position.
J Virol. 1991 Feb ;65(2):904-12.

PubMed
Trim5alpha accelerates degradation of cytosolic capsid associated with productiv...
Trim5alpha accelerates degradation of cytosolic capsid associated with productive HIV-1 entry.
J Biol Chem. 2006 Dec 1 ;281(48):37025-33. Epub 2006 Oct 6 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Literature > PubMed

Write to the Help Desk