Bioessays. 2006 Oct;28(10):973-8.

Duplication, divergence and formation of novel protein topologies.

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Institute for Cellular and Molecular Biology, University of Texas at Austin, TX, USA. cvogel@mail.utexas.edu

Abstract

The rearrangement or permutation of protein substructures is an important mode of divergence. Recent work explored one possible underlying mechanism called permutation-by-duplication, which produces special forms of motif rearrangements called circular permutations. Permutation-by-duplication, involving gene duplication, fusion and truncation, can produce fully functional intermediate proteins and thus represents a feasible mechanism of protein evolution. In spite of this, circular permutations are relatively rare and we discuss possible reasons for their existence.

PMID:: 16998824; [PubMed - indexed for MEDLINE]

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