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    Immunol Lett. 1990 Jul;24(4):253-60.

    Peptide vaccines derived from a malarial surface antigen: effects of dose and adjuvants on immunogenicity.

    Jones GL, Spencer L, Lord R, Mollard R, Pye D, Saul A.

    Source

    Queensland Institute of Medical Research, Herston, Australia.

    Abstract

    Peptides P2122 (CKNNNSTNSGI) and P513 (CSQRSTNSAST) containing an epitope of a malarial surface antigen (MSA2) recognised by inhibitory monoclonal antibodies were conjugated to diphtheria toxoid (DT) protein and formulated with various gel-based and water in oil emulsion adjuvants in vaccine trials in mice and rabbits. The P2122-DT construct was effective in raising antibodies reactive with both the immunising peptide and the native antigen. Effective adjuvanticity as measured by the titre of the anti-peptide or anti-protein response in mice varied in the order: Algammulin, Montanide ISA 50 greater than or equal to Freund's adjuvant, Montanide ISA 708, 721, 70 much greater than alum, Squalene Arlacel greater than SAF-1. A similar order of adjuvant efficacy: Freund's greater than alum greater than Squalene Arlacel greater than SAF-1, was observed in rabbits.

    PMID:
    1697281
    [PubMed - indexed for MEDLINE]

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