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    J Virol. 1990 Jul;64(7):3376-81.

    Abrogation of Fv-1 restriction by genome-deficient virions produced by a retrovirus packaging cell line.

    Source

    Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

    Abstract

    The Fv-1b-mediated restriction of N-tropic retrovirus vector infection of BALB/3T3 cells was partially abrogated by prior infection with N-tropic murine leukemia virus. Likewise, abrogation of the Fv-1b restriction of N-tropic murine leukemia virus replication was accomplished by prior infection with genome-deficient virions produced by an N-tropic murine leukemia virus packaging cell line. The latter observation suggests that the Fv-1 target in genome-deficient virions abrogates Fv-1 restriction in the absence of any viral genome-directed processes.

    PMID:
    1693703
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC249585
    Free PMC Article

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