Trends Pharmacol Sci. 2006 Sep;27(9):458-60. Epub 2006 Jul 25.

GPCR antagonists as an alternative to COX-2 inhibitors: a case for the PGE2 EP1 receptor.

Source

Departments of Anesthesiology and Critical Care Medicine, and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. sdore@jhmi.edu

Abstract

A recent article supports the concept that prostaglandin (PG)E(2) EP(1)-receptor antagonists reduce stroke severity and cell damage; could these agents become a substitute for cyclooxygenase (COX)-2 inhibitors? The total activity of COXs--rate-limiting enzymes of PGE(2) synthesis--increases following acute neurological insult. Drugs that offer the beneficial anti-inflammatory and neuroprotective effects of PGs but that limit the negative effects of COX-2 inhibition could provide the next generation of treatment for acute neuronal damage.

PMID:: 16870271; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, N.I.H., Extramural

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Pain Relievers - MedlinePlus Health Information

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Microglial inhibition of neuroprotection by antagonists of the EP1 prostaglandin E2 receptor. [J Neuroinflammation. 2009]
Microglial inhibition of neuroprotection by antagonists of the EP1 prostaglandin E2 receptor.
Carlson NG, Rojas MA, Black JD, Redd JW, Hille J, Hill KE, Rose JW. J Neuroinflammation. 2009 Feb 17; 6:5. Epub 2009 Feb 17.
Review Targeting prostaglandin E EP receptors to inhibit metastasis. [Cancer Res. 2006]
Review Targeting prostaglandin E EP receptors to inhibit metastasis.
Fulton AM, Ma X, Kundu N. Cancer Res. 2006 Oct 15; 66(20):9794-7.
Effects of selective PGE2 receptor antagonists in esophageal adenocarcinoma cells derived from Barrett's esophagus. [Prostaglandins Other Lipid Med...]
Effects of selective PGE2 receptor antagonists in esophageal adenocarcinoma cells derived from Barrett's esophagus.
Piazuelo E, Jiménez P, Strunk M, Santander S, García A, Esteva F, Lanas A. Prostaglandins Other Lipid Mediat. 2006 Dec; 81(3-4):150-61. Epub 2006 Oct 6.
Contribution of the prostaglandin E2/E-prostanoid 2 receptor signaling pathway in abscess formation in rat zymosan-induced pleurisy. [J Pharmacol Exp Ther. 2009]
Contribution of the prostaglandin E2/E-prostanoid 2 receptor signaling pathway in abscess formation in rat zymosan-induced pleurisy.
Inada T, Arai K, Kawamura M, Hatanaka K, Sato Y, Noshiro M, Harada Y. J Pharmacol Exp Ther. 2009 Dec; 331(3):860-70. Epub 2009 Sep 2.
Review A proposed COX-2 and PGE(2) receptor interaction in UV-exposed mouse skin. [Mol Carcinog. 2007]
Review A proposed COX-2 and PGE(2) receptor interaction in UV-exposed mouse skin.
Chun KS, Langenbach R. Mol Carcinog. 2007 Aug; 46(8):699-704.

See reviews... See all...

Cited by 9 PubMed Central articles

Prostaglandin E receptor EP1 suppresses breast cancer metastasis and is linked to survival differences and cancer disparities. [Mol Cancer Res. 2010]
Prostaglandin E receptor EP1 suppresses breast cancer metastasis and is linked to survival differences and cancer disparities.
Ma X, Kundu N, Ioffe OB, Goloubeva O, Konger R, Baquet C, Gimotty P, Reader J, Fulton AM. Mol Cancer Res. 2010 Oct; 8(10):1310-8. Epub 2010 Sep 21.
The PGE2 EP2 receptor and its selective activation are beneficial against ischemic stroke. [Exp Transl Stroke Med. 2010]
The PGE2 EP2 receptor and its selective activation are beneficial against ischemic stroke.
Ahmad M, Saleem S, Shah Z, Maruyama T, Narumiya S, Doré S. Exp Transl Stroke Med. 2010 Jul 8; 2(1):12. Epub 2010 Jul 8.
Microsomal prostaglandin E synthase-2: cellular distribution and expression in Alzheimer's disease. [Exp Neurol. 2010]
Microsomal prostaglandin E synthase-2: cellular distribution and expression in Alzheimer's disease.
Chaudhry U, Zhuang H, Doré S. Exp Neurol. 2010 Jun; 223(2):359-65. Epub 2009 Aug 5.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

GPCR antagonists as an alternative to COX-2 inhibitors: a case for the PGE2 EP1 ...
GPCR antagonists as an alternative to COX-2 inhibitors: a case for the PGE2 EP1 receptor.
Trends Pharmacol Sci. 2006 Sep ;27(9):458-60. Epub 2006 Jul 25 .

PubMed
Factor XI activation in a revised model of blood coagulation.
Factor XI activation in a revised model of blood coagulation.
Science. 1991 Aug 23 ;253(5022):909-12.

PubMed
Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized co...
Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled trial.
CMAJ. 2006 Mar 28 ;174(7):927-33. Epub 2006 Mar 3 .

PubMed
Middle cerebral artery occlusion in rats: a neurological and pathological evalua...
Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model.
Neurosurgery. 1992 Jul ;31(1):100-6; discussion 106-7.

PubMed
Ligands to FGF receptor 2-IIIb induce proliferation, motility, protection from c...
Ligands to FGF receptor 2-IIIb induce proliferation, motility, protection from cell death and cytoskeletal rearrangements in epithelial ovarian cancer cell lines.
Growth Factors. 2006 Mar ;24(1):45-53.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: