Curr Rheumatol Rep. 2006 Aug;8(4):283-6.

Biomarkers in spondyloarthritis.

Source

The Arthritis Center of Excellence, Toronto Western Hospital, Toronto, Ontario, Canada M5T 2S8.

Abstract

In spondyloarthritis, in particular ankylosing spondylitis (AS), a need exists for clinically meaningful biomarkers, both for diagnosis and prognosis. Earlier diagnosis has become an imperative since the advent of biologic therapy, which has proved effective in controlling axial inflammation. Presently, however, there are no biomarkers that reliably distinguish inflammatory back pain from the far more prevalent mechanical back pain. The target sites in AS--sacroiliac joints and the spine--are relatively inaccessible to the investigator and clinician, so defining markers associated with or predictive of axial inflammation remains an important goal. Cytokines, metalloproteinases, and cartilage catabolic products are all candidates for the important role of biomarker in spondyloarthritis.

PMID:: 16839507; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Biological Markers

LinkOut - more resources

Full Text Sources

Medical

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment. [Arthritis Res Ther. 2008]
Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment.
Appel H, Janssen L, Listing J, Heydrich R, Rudwaleit M, Sieper J. Arthritis Res Ther. 2008; 10(5):R125. Epub 2008 Oct 22.
Whole body MR imaging in ankylosing spondylitis: a descriptive pilot study in patients with suspected early and active confirmed ankylosing spondylitis. [BMC Musculoskelet Disord. 2007]
Whole body MR imaging in ankylosing spondylitis: a descriptive pilot study in patients with suspected early and active confirmed ankylosing spondylitis.
Weber U, Pfirrmann CW, Kissling RO, Hodler J, Zanetti M. BMC Musculoskelet Disord. 2007 Feb 27; 8:20. Epub 2007 Feb 27.
Review Magnetic resonance imaging in ankylosing spondylitis. [Curr Opin Rheumatol. 2007]
Review Magnetic resonance imaging in ankylosing spondylitis.
Zochling J, Baraliakos X, Hermann KG, Braun J. Curr Opin Rheumatol. 2007 Jul; 19(4):346-52.
Serum monocyte chemotactic protein-1 concentrations distinguish patients with ankylosing spondylitis from patients with mechanical low back pain. [J Spinal Disord Tech. 2011]
Serum monocyte chemotactic protein-1 concentrations distinguish patients with ankylosing spondylitis from patients with mechanical low back pain.
Romero-Sanchez C, Tsou HK, Jan MS, Wong RH, Chang IC, Londoño J, Valle-Oñate R, Howe HS, Yu D, Leung BP, et al. J Spinal Disord Tech. 2011 May; 24(3):202-7.
Review Soluble and tissue biomarkers in ankylosing spondylitis. [Best Pract Res Clin Rheumatol....]
Review Soluble and tissue biomarkers in ankylosing spondylitis.
de Vlam K. Best Pract Res Clin Rheumatol. 2010 Oct; 24(5):671-82.

See reviews... See all...

Cited by 1 PubMed Central article

Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. [Arthritis Res Ther. 2008]
Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues.
Melrose J, Fuller ES, Roughley PJ, Smith MM, Kerr B, Hughes CE, Caterson B, Little CB. Arthritis Res Ther. 2008; 10(4):R79. Epub 2008 Jul 14.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Biomarkers in spondyloarthritis.
Biomarkers in spondyloarthritis.
Curr Rheumatol Rep. 2006 Aug ;8(4):283-6.

PubMed
Involvement of macrophages and dendritic cells in synovial inflammation of colla...
Involvement of macrophages and dendritic cells in synovial inflammation of collagen induced arthritis in DBA/1 mice and spontaneous arthritis in MRL/lpr mice.
Autoimmunity. 1991 ;8(4):271-80.

PubMed
Radioimmunotherapy of head and neck cancer xenografts using 131I-labeled antibod...
Radioimmunotherapy of head and neck cancer xenografts using 131I-labeled antibody L19-SIP for selective targeting of tumor vasculature.
J Nucl Med. 2006 Jul ;47(7):1127-35.

PubMed
Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis...
Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis.
Lancet. 1991 Oct 12 ;338(8772):899-902.

PubMed
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to ...
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
Mol Cell Biol. 2006 Jul ;26(14):5518-27.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: