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    Science. 1991 Oct 4;254(5028):112-4.

    Molecular cloning of an invertebrate glutamate receptor subunit expressed in Drosophila muscle.

    Schuster CM, Ultsch A, Schloss P, Cox JA, Schmitt B, Betz H.

    Source

    Zentrum für Molekulare Biologie, Universität Heidelberg, Federal Republic of Germany.

    Abstract

    Insects and other invertebrates use glutamate as a neurotransmitter in the central nervous system and at the neuromuscular junction. A complementary DNA from Drosophila melanogaster, designated DGluR-II, has been isolated that encodes a distant homolog of the cloned mammalian ionotropic glutamate receptor family and is expressed in somatic muscle tissue of Drosophila embryos. Electrophysiological recordings made in Xenopus oocytes that express DGluR-II revealed depolarizing responses to L-glutamate and L-aspartate but low sensitivity to quisqualate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), and kainate. The DGluR-II protein may represent a distinct glutamate receptor subtype, which shares its structural design with other members of the ionotropic glutamate receptor family.

    PMID:
    1681587
    [PubMed - indexed for MEDLINE]

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