Int J Clin Pharmacol Res. 1991;11(1):35-40.

Alcoholic abstinence syndrome: short-term treatment with metadoxine.

Bono G, Sinforiani E, Merlo P, Belloni G, Soldati M, Gelso E.

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Third Department of Neurology, Intituto Ricovero e Cura a Carattesre Scientifico (IRCCS) C. Mondino, University of Pavia, Italy.

Abstract

The effects of metadoxine (pyrrolidone carboxylate of pyridoxine), a compound with central benzodiazepine-like properties, were evaluated in two groups of chronic alcoholics (inpatients) presenting a mild withdrawal syndrome. According to a double-blind study design 20 patients received metadoxine 900 mg twice daily eluted in 500 ml of saline infusion, while 20 (the control group) were given 500 ml of saline infusion twice daily with equivalent doses of pyridoxine (40 mg/die) every morning over a 10-day period. The results indicate that metadoxine treatment was able to control alcohol abstinence, thus allowing a reduction in the needs for standard benzodiazepine therapy. The central activity of gamma-aminobutyric acid of this compound might play a crucial role in the clinical effects demonstrated.

PMID:: 1678735; [PubMed - indexed for MEDLINE]

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[Therapeutic use of metadoxine in chronic alcoholism. Double blind study of patients in a department of general medicine]. [Clin Ter. 1993]
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