Cereb Cortex. 2006 Jul;16 Suppl 1:i69-73.

The doublecortin and doublecortin-like kinase 1 genes cooperate in murine hippocampal development.

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Neurogenetics Laboratory, Department of Neurosciences, University of California, San Diego, CA, USA.

Abstract

The doublecortin (Dcx) and doublecortin-like kinase 1 (Dclk) genes are developmentally expressed neuronal microtubule-associated proteins. Humans with DCX mutations show a severe defect in hippocampal development, but targeted deletion in mouse shows only a defect in pyramidal neuron lamination. There is significant sequence overlap between Dcx and Dclk, suggesting functional redundancy. Here we show that the two genes display overlapping expression patterns in developing mouse hippocampus. Targeted deletion of Dclk shows no appreciable developmental defect in the hippocampus, but removal of both genes shows severe hippocampal lamination defects involving the entire cornu ammonis and dentate gyrus fields that mimic the human phenotype. These results suggest these genes are partially functionally redundant in the formation of the murine hippocampus.

PMID:: 16766710; [PubMed - indexed for MEDLINE]

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The doublecortin and doublecortin-like kinase 1 genes cooperate in murine hippoc...
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The doublecortin and doublecortin-like kinase 1 genes cooperate in murine hippocampal development.

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