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    Nature. 1991 Jun 13;351(6327):542-7.

    Genetic analysis of autoimmune type 1 diabetes mellitus in mice.

    Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JR, Hearne CM, Knight AM, Love JM, McAleer MA, Prins JB, et al.

    Source

    Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford, UK.

    Abstract

    Two genes, Idd-3 and Idd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 major histocompatibility complex. A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study. On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17.

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    PMID:
    1675432
    [PubMed - indexed for MEDLINE]

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