Mutat Res. 1991 May;248(1):1-15.

A bacterial position effect: when the F factor in E. coli K12 is integrated in cis to a chromosomal gene that is flanked by IS1 repeats the elements are activated so that amplification and other regulatory changes that affect the gene can occur.

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CRC Department of Medical Oncology, Beatson Institute for Cancer Research, Bearsden, Glasgow, Great Britain.

Abstract

In Escherichia coli K12 the argF gene is located within Tn2901, a genomic unit of approx. 12 kb that is flanked by IS1 elements in direct repeat. When strains in which the F factor is integrated in cis to Tn2901 are subjected to the appropriate selection, regulatory changes that result in over-production of the argF-encoded ornithine transcarbamylase occur at relatively high frequencies. When amplification occurs, the F factor is required only for the initial exchange between the IS1 elements, homologous recombination between tandem repeats of Tn2901 being independent of the F status of the cell. While amplification of Tn2901 is frequent in some Hfr strains, in others regulatory changes that do not involve amplification are predominant. The transfer region of the F factor does not contribute to the position effect.

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Mapping of IS1 elements flanking the argF gene region on the Escherichia coli K-12 chromosome. [Mol Gen Genet. 1981]
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