Lancet. 1991 May 11;337(8750):1137-9.

Treatment of systemic vasculitis with pooled intravenous immunoglobulin.

Jayne DR, Davies MJ, Fox CJ, Black CM, Lockwood CM.

Source

Department of Medicine, School of Clinical Medicine, University of Cambridge, UK.

Abstract

The therapeutic effect of a course of high-dose, pooled, intravenous immunoglobulin (IVIg) on disease activity and circulating antineutrophil cytoplasm antibodies (ANCA) was investigated in 7 patients with systemic vasculitis. 5 had active disease despite conventional immunosuppression, and 2 had not received any treatment. All 7 had clinical improvement, which was sustained in 6 and transient in 1. The fall in ANCA concentrations to a mean of 51% of the pre-treatment values was maintained during follow-up. C-reactive protein concentration also dropped considerably. IVIg seemed to confer a useful therapeutic effect without adverse reaction.

PMID:: 1674023; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Vasculitis - MedlinePlus Health Information

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Pooled intravenous immunoglobulin in the management of systemic vasculitis. [Adv Exp Med Biol. 1993]
Pooled intravenous immunoglobulin in the management of systemic vasculitis.
Jayne DR, Lockwood CM. Adv Exp Med Biol. 1993; 336:469-72.
Treatment of antineutrophil cytoplasmic autoantibody-positive systemic vasculitis and glomerulonephritis with pooled intravenous gammaglobulin. [Am J Kidney Dis. 1992]
Treatment of antineutrophil cytoplasmic autoantibody-positive systemic vasculitis and glomerulonephritis with pooled intravenous gammaglobulin.
Tuso P, Moudgil A, Hay J, Goodman D, Kamil E, Koyyana R, Jordan SC. Am J Kidney Dis. 1992 Nov; 20(5):504-8.
Treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis with high-dose intravenous immunoglobulin. [Clin Exp Immunol. 1995]
Treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis with high-dose intravenous immunoglobulin.
Richter C, Schnabel A, Csernok E, De Groot K, Reinhold-Keller E, Gross WL. Clin Exp Immunol. 1995 Jul; 101(1):2-7.
Review ANCA anti-idiotype antibodies and the treatment of systemic vasculitis with intravenous immunoglobulin. [J Autoimmun. 1993]
Review ANCA anti-idiotype antibodies and the treatment of systemic vasculitis with intravenous immunoglobulin.
Jayne DR, Esnault VL, Lockwood CM. J Autoimmun. 1993 Apr; 6(2):207-19.
Review Treatment of autoimmune diseases and systemic vasculitis with pooled human intravenous immune globulin. [Clin Exp Immunol. 1994]
Review Treatment of autoimmune diseases and systemic vasculitis with pooled human intravenous immune globulin.
Jordan SC, Toyoda M. Clin Exp Immunol. 1994 Jul; 97 Suppl 1:31-8.

See reviews... See all...

Cited by 27 PubMed Central articles

Review Clinical applications of intravenous immunoglobulins (IVIg)--beyond immunodeficiencies and neurology. [Clin Exp Immunol. 2009]
Review Clinical applications of intravenous immunoglobulins (IVIg)--beyond immunodeficiencies and neurology.
Hartung HP, Mouthon L, Ahmed R, Jordan S, Laupland KB, Jolles S. Clin Exp Immunol. 2009 Dec; 158 Suppl 1:23-33.
Review Advances in the use of biologic agents for the treatment of systemic vasculitis. [Curr Opin Rheumatol. 2009]
Review Advances in the use of biologic agents for the treatment of systemic vasculitis.
Chung SA, Seo P. Curr Opin Rheumatol. 2009 Jan; 21(1):3-9.
Review Induction of remission in active anti-neutrophil cytoplasmic antibody-associated vasculitis with mycophenolate mofetil in patients who cannot be treated with cyclophosphamide. [Ann Rheum Dis. 2007]
Review Induction of remission in active anti-neutrophil cytoplasmic antibody-associated vasculitis with mycophenolate mofetil in patients who cannot be treated with cyclophosphamide.
Stassen PM, Tervaert JW, Stegeman CA. Ann Rheum Dis. 2007 Jun; 66(6):798-802. Epub 2006 Dec 19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Treatment of systemic vasculitis with pooled intravenous immunoglobulin.
Treatment of systemic vasculitis with pooled intravenous immunoglobulin.
Lancet. 1991 May 11 ;337(8750):1137-9.

PubMed
Increased intima-media thickness after early-onset preeclampsia.
Increased intima-media thickness after early-onset preeclampsia.
Obstet Gynecol. 2006 Jun ;107(6):1345-51.

PubMed
Denaturation of polyoma DNA by phage T4 gene 32 protein.
Denaturation of polyoma DNA by phage T4 gene 32 protein.
Nature. 1975 May 15 ;255(5505):249-52.

PubMed
Reduction of graft-versus-host disease by histone deacetylase inhibitor suberony...
Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1.
Exp Hematol. 2006 Jun ;34(6):776-87.

PubMed
HLA class I typing by PCR: HLA-B27 and an African B27 subtype.
HLA class I typing by PCR: HLA-B27 and an African B27 subtype.
Lancet. 1991 Mar 16 ;337(8742):640-2.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Treatment of systemic vasculitis with pooled intravenous immunoglobulin.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 27 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information