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    Immunogenetics. 2006 Jun;58(5-6):471-3. Epub 2006 May 5.

    IL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population.

    Segat L, Bevilacqua D, Boniotto M, Arraes LC, de Souza PR, de Lima Filho JL, Crovella S.

    Source

    Department of Reproductive and Developmental Sciences, University of Trieste, Via dell'Istria 65/1, Trieste, Italy. segat@burlo.trieste.it

    Abstract

    In our study, we identified a polymorphism (C-607A) in the promoter region of the IL-18 gene that shows different frequencies between human immunodeficiency virus (HIV)-1-infected children and healthy controls in a pediatric Brazilian population. The presence of the -607 C allele correlates to HIV-1 infection and confers an increased risk of infection in subjects carrying the single nucleotide polymorphism.

    PMID:
    16738942
    [PubMed - indexed for MEDLINE]

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